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Agonist-induced formation of unproductive receptor-G12 complexes.
Okashah N, Wright SC, Kawakami K, Mathiasen S, Zhou J, Lu S, Javitch JA, Inoue A, Bouvier M, Lambert NA. Okashah N, et al. Among authors: bouvier m. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21723-21730. doi: 10.1073/pnas.2003787117. Epub 2020 Aug 17. Proc Natl Acad Sci U S A. 2020. PMID: 32817560 Free PMC article.
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Brouwers B, et al. Among authors: bouvier m. Cell Rep. 2021 Mar 23;34(12):108862. doi: 10.1016/j.celrep.2021.108862. Cell Rep. 2021. PMID: 33761344 Free PMC article.
GPCR activation mechanisms across classes and macro/microscales.
Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DE. Hauser AS, et al. Among authors: bouvier m. Nat Struct Mol Biol. 2021 Nov;28(11):879-888. doi: 10.1038/s41594-021-00674-7. Epub 2021 Nov 10. Nat Struct Mol Biol. 2021. PMID: 34759375 Free PMC article.
809 results