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Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.
Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R. Shah PP, et al. Among authors: frank db. Cell Stem Cell. 2021 May 6;28(5):938-954.e9. doi: 10.1016/j.stem.2020.12.016. Epub 2021 Feb 1. Cell Stem Cell. 2021. PMID: 33529599 Free PMC article.
Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.
Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML. Goddard LM, et al. Among authors: frank db. Dev Cell. 2017 Nov 6;43(3):274-289.e5. doi: 10.1016/j.devcel.2017.09.023. Epub 2017 Oct 19. Dev Cell. 2017. PMID: 29056552 Free PMC article.
Early lineage specification defines alveolar epithelial ontogeny in the murine lung.
Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M, Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE. Frank DB, et al. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4362-4371. doi: 10.1073/pnas.1813952116. Epub 2019 Feb 19. Proc Natl Acad Sci U S A. 2019. PMID: 30782824 Free PMC article.
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP. Obraztsova K, et al. Among authors: frank db. Nat Commun. 2020 Nov 6;11(1):5640. doi: 10.1038/s41467-020-18979-4. Nat Commun. 2020. PMID: 33159078 Free PMC article.
Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus.
Zepp JA, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, Burdick JA, Morrisey EE. Zepp JA, et al. Among authors: frank db. Science. 2021 Mar 12;371(6534):eabc3172. doi: 10.1126/science.abc3172. Science. 2021. PMID: 33707239 Free PMC article.
57 results