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Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Quinton RJ, et al. Among authors: ganem nj. Nature. 2021 Feb;590(7846):492-497. doi: 10.1038/s41586-020-03133-3. Epub 2021 Jan 27. Nature. 2021. PMID: 33505027 Free PMC article.
DNA breaks and chromosome pulverization from errors in mitosis.
Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D. Crasta K, et al. Among authors: ganem nj. Nature. 2012 Jan 18;482(7383):53-8. doi: 10.1038/nature10802. Nature. 2012. PMID: 22258507 Free PMC article.
Generation and Purification of Tetraploid Cells.
Shenk EM, Ganem NJ. Shenk EM, et al. Among authors: ganem nj. Methods Mol Biol. 2016;1413:393-401. doi: 10.1007/978-1-4939-3542-0_24. Methods Mol Biol. 2016. PMID: 27193862 Free PMC article.
CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels.
Quinton RJ, Ganem NJ. Quinton RJ, et al. Among authors: ganem nj. Methods Mol Biol. 2019;1893:203-214. doi: 10.1007/978-1-4939-8910-2_16. Methods Mol Biol. 2019. PMID: 30565136 Free PMC article.
Identification of the kinase STK25 as an upstream activator of LATS signaling.
Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Lim S, et al. Among authors: ganem nj. Nat Commun. 2019 Apr 4;10(1):1547. doi: 10.1038/s41467-019-09597-w. Nat Commun. 2019. PMID: 30948712 Free PMC article.
34 results