Amano Y - Search Results

1

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.

Kuriwaki I, Kameda M, Iikubo K, Hisamichi H, Kawamoto Y, Kikuchi S, Moritomo H, Kondoh Y, Terasaka T, Amano Y, Tateishi Y, Echizen Y, Iwai Y, Noda A, Tomiyama H, Nakazawa T, Hirano M. Kuriwaki I, et al. Among authors: amano y. Bioorg Med Chem. 2021 Mar 1;33:116019. doi: 10.1016/j.bmc.2021.116019. Epub 2021 Jan 16. Bioorg Med Chem. 2021. PMID: 33486159

2

Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition.

Hamaguchi W, Masuda N, Isomura M, Miyamoto S, Kikuchi S, Amano Y, Honbou K, Mihara T, Watanabe T. Hamaguchi W, et al. Among authors: amano y. Bioorg Med Chem. 2013 Dec 15;21(24):7612-23. doi: 10.1016/j.bmc.2013.10.035. Epub 2013 Oct 31. Bioorg Med Chem. 2013. PMID: 24238902

3

Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography.

Amano Y, Yamaguchi T, Tanabe E. Amano Y, et al. Bioorg Med Chem. 2014 Apr 15;22(8):2427-34. doi: 10.1016/j.bmc.2014.03.001. Epub 2014 Mar 12. Bioorg Med Chem. 2014. PMID: 24656800

4

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability.

Chino A, Masuda N, Amano Y, Honbou K, Mihara T, Yamazaki M, Tomishima M. Chino A, et al. Among authors: amano y. Bioorg Med Chem. 2014 Jul 1;22(13):3515-26. doi: 10.1016/j.bmc.2014.04.023. Epub 2014 Apr 20. Bioorg Med Chem. 2014. PMID: 24837154

5

Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.

Hamaguchi W, Masuda N, Miyamoto S, Shiina Y, Kikuchi S, Mihara T, Moriguchi H, Fushiki H, Murakami Y, Amano Y, Honbou K, Hattori K. Hamaguchi W, et al. Among authors: amano y. Bioorg Med Chem. 2015 Jan 15;23(2):297-313. doi: 10.1016/j.bmc.2014.11.039. Epub 2014 Dec 3. Bioorg Med Chem. 2015. PMID: 25515954

6

Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening.

Amano Y, Tanabe E, Yamaguchi T. Amano Y, et al. Bioorg Med Chem. 2015 May 15;23(10):2310-7. doi: 10.1016/j.bmc.2015.03.083. Epub 2015 Apr 6. Bioorg Med Chem. 2015. PMID: 25862210

7

Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436.

Hamaguchi W, Masuda N, Miyamoto S, Kikuchi S, Narazaki F, Shiina Y, Seo R, Amano Y, Mihara T, Moriguchi H, Hattori K. Hamaguchi W, et al. Among authors: amano y. Bioorg Med Chem. 2015 Jul 1;23(13):3351-67. doi: 10.1016/j.bmc.2015.04.052. Epub 2015 Apr 25. Bioorg Med Chem. 2015. PMID: 25960322

8

Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.

Amano Y, Namatame I, Tateishi Y, Honboh K, Tanabe E, Niimi T, Sakashita H. Amano Y, et al. Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1879-89. doi: 10.1107/S1399004715013048. Epub 2015 Aug 25. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26327378

9

In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.

Yoshino R, Yasuo N, Hagiwara Y, Ishida T, Inaoka DK, Amano Y, Tateishi Y, Ohno K, Namatame I, Niimi T, Orita M, Kita K, Akiyama Y, Sekijima M. Yoshino R, et al. Among authors: amano y. Sci Rep. 2017 Jul 27;7(1):6666. doi: 10.1038/s41598-017-06411-9. Sci Rep. 2017. PMID: 28751689 Free PMC article.

10

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

Hamaguchi H, Amano Y, Moritomo A, Shirakami S, Nakajima Y, Nakai K, Nomura N, Ito M, Higashi Y, Inoue T. Hamaguchi H, et al. Among authors: amano y. Bioorg Med Chem. 2018 Oct 1;26(18):4971-4983. doi: 10.1016/j.bmc.2018.08.005. Epub 2018 Aug 4. Bioorg Med Chem. 2018. PMID: 30145050

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