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Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS. Abril YLN, et al. Among authors: lin h. Oncogene. 2021 Mar;40(9):1644-1658. doi: 10.1038/s41388-020-01637-w. Epub 2021 Jan 21. Oncogene. 2021. PMID: 33479498 Free PMC article.
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H. Du J, et al. Among authors: lin h. Science. 2011 Nov 11;334(6057):806-9. doi: 10.1126/science.1207861. Science. 2011. PMID: 22076378 Free PMC article.
Thiosuccinyl peptides as Sirt5-specific inhibitors.
He B, Du J, Lin H. He B, et al. Among authors: lin h. J Am Chem Soc. 2012 Feb 1;134(4):1922-5. doi: 10.1021/ja2090417. Epub 2012 Jan 20. J Am Chem Soc. 2012. PMID: 22263694 Free PMC article.
A fluorogenic assay for screening Sirt6 modulators.
Hu J, He B, Bhargava S, Lin H. Hu J, et al. Among authors: lin h. Org Biomol Chem. 2013 Aug 28;11(32):5213-6. doi: 10.1039/c3ob41138a. Org Biomol Chem. 2013. PMID: 23839075 Free PMC article.
Metabolic characterization of a Sirt5 deficient mouse model.
Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J. Yu J, et al. Among authors: lin h. Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806. Sci Rep. 2013. PMID: 24076663 Free PMC article.
Sirtuin inhibitors as anticancer agents.
Hu J, Jing H, Lin H. Hu J, et al. Among authors: lin h. Future Med Chem. 2014 May;6(8):945-66. doi: 10.4155/fmc.14.44. Future Med Chem. 2014. PMID: 24962284 Free PMC article. Review.
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