Wender PA - Search Results

1

Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation.

Abramson E, Hardman C, Shimizu AJ, Hwang S, Hester LD, Snyder SH, Wender PA, Kim PM, Kornberg MD. Abramson E, et al. Among authors: wender pa. Cell Chem Biol. 2021 Apr 15;28(4):537-545.e4. doi: 10.1016/j.chembiol.2020.12.015. Epub 2021 Jan 19. Cell Chem Biol. 2021. PMID: 33472023 Free PMC article.

2

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR. Wender PA, et al. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6624-9. doi: 10.1073/pnas.95.12.6624. Proc Natl Acad Sci U S A. 1998. PMID: 9618462 Free PMC article.

3

Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.

Wender PA, Lippa B, Park CM, Irie K, Nakahara A, Ohigashi H. Wender PA, et al. Bioorg Med Chem Lett. 1999 Jun 21;9(12):1687-90. doi: 10.1016/s0960-894x(99)00263-2. Bioorg Med Chem Lett. 1999. PMID: 10397502 Free article.

4

The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues.

Wender PA, Hinkle KW, Koehler MF, Lippa B. Wender PA, et al. Med Res Rev. 1999 Sep;19(5):388-407. doi: 10.1002/(sici)1098-1128(199909)19:5<388::aid-med6>3.0.co;2-h. Med Res Rev. 1999. PMID: 10502742 Review.

5

The practical synthesis of a novel and highly potent analogue of bryostatin.

Wender PA, Baryza JL, Bennett CE, Bi FC, Brenner SE, Clarke MO, Horan JC, Kan C, Lacôte E, Lippa B, Nell PG, Turner TM. Wender PA, et al. J Am Chem Soc. 2002 Nov 20;124(46):13648-9. doi: 10.1021/ja027509+. J Am Chem Soc. 2002. PMID: 12431074

6

Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP.

Baryza JL, Brenner SE, Craske ML, Meyer T, Wender PA. Baryza JL, et al. Among authors: wender pa. Chem Biol. 2004 Sep;11(9):1261-7. doi: 10.1016/j.chembiol.2004.06.014. Chem Biol. 2004. PMID: 15380186

7

Identification of a tunable site in bryostatin analogs: C20 Bryologs through late stage diversification.

Wender PA, Baryza JL. Wender PA, et al. Org Lett. 2005 Mar 17;7(6):1177-80. doi: 10.1021/ol0501931. Org Lett. 2005. PMID: 15760168

8

Role of the A-ring of bryostatin analogues in PKC binding: synthesis and initial biological evaluation of new A-ring-modified bryologs.

Wender PA, Clarke MO, Horan JC. Wender PA, et al. Org Lett. 2005 May 12;7(10):1995-8. doi: 10.1021/ol0504650. Org Lett. 2005. PMID: 15876038

9

Function oriented synthesis: the design, synthesis, PKC binding and translocation activity of a new bryostatin analog.

Wender PA, Baryza JL, Brenner SE, Clarke MO, Craske ML, Horan JC, Meyer T. Wender PA, et al. Curr Drug Discov Technol. 2004 Jan;1(1):1-11. doi: 10.2174/1570163043484888. Curr Drug Discov Technol. 2004. PMID: 16472215

10

Design, synthesis, and biological evaluation of a potent, PKC selective, B-ring analog of bryostatin.

Wender PA, Verma VA. Wender PA, et al. Org Lett. 2006 Apr 27;8(9):1893-6. doi: 10.1021/ol060457z. Org Lett. 2006. PMID: 16623578

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