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Page 1
The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes.
Hörömpöli D, Ciglia C, Glüsenkamp KH, Haustedt LO, Falkenstein-Paul H, Bendas G, Berscheid A, Brötz-Oesterhelt H. Hörömpöli D, et al. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e00986-20. doi: 10.1128/AAC.00986-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33468467 Free PMC article.
How many modes of action should an antibiotic have?
Brötz-Oesterhelt H, Brunner NA. Brötz-Oesterhelt H, et al. Curr Opin Pharmacol. 2008 Oct;8(5):564-73. doi: 10.1016/j.coph.2008.06.008. Epub 2008 Jul 30. Curr Opin Pharmacol. 2008. PMID: 18621146 Review.
Human commensals producing a novel antibiotic impair pathogen colonization.
Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B. Zipperer A, et al. Nature. 2016 Jul 28;535(7613):511-6. doi: 10.1038/nature18634. Nature. 2016. PMID: 27466123
Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.
Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. Mokhlesi A, et al. J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2. J Nat Prod. 2017. PMID: 29094598
Rhodomyrtone (Rom) is a membrane-active compound.
Saising J, Nguyen MT, Härtner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, Muehlenkamp M, Schäkermann S, Kumari N, Maier ME, Voravuthikunchai SP, Bandow J, Lang F, Brötz-Oesterhelt H, Götz F. Saising J, et al. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1114-1124. doi: 10.1016/j.bbamem.2018.01.011. Epub 2018 Jan 6. Biochim Biophys Acta Biomembr. 2018. PMID: 29317198 Free article.
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability.
Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán-Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond S. Schilling NA, et al. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9234-9238. doi: 10.1002/anie.201901589. Epub 2019 May 27. Angew Chem Int Ed Engl. 2019. PMID: 31059155 Free PMC article.
89 results