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Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments.
Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Fiala GJ, Agudelo LZ, Dyck L, Kane H, Douglas A, Cunningham S, Prendeville H, Loftus R, Carmody C, Pierre P, Kellis M, Brenner M, Argüello RJ, Silva-Santos B, Pennington DJ, Lynch L. Lopes N, et al. Among authors: douglas a. Nat Immunol. 2021 Feb;22(2):179-192. doi: 10.1038/s41590-020-00848-3. Epub 2021 Jan 18. Nat Immunol. 2021. PMID: 33462452 Free PMC article.
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L. Dyck L, et al. Among authors: douglas a. J Exp Med. 2022 Mar 7;219(3):e20210042. doi: 10.1084/jem.20210042. Epub 2022 Feb 1. J Exp Med. 2022. PMID: 35103755 Free PMC article.
Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L. Dyck L, et al. Among authors: douglas a. J Exp Med. 2022 Mar 7;219(3):jem.2021004202072022c. doi: 10.1084/jem.2021004202072022c. Epub 2022 Feb 28. J Exp Med. 2022. PMID: 35226044 Free PMC article. No abstract available.
Interleukin-17 as a key player in neuroimmunometabolism.
Douglas A, Stevens B, Lynch L. Douglas A, et al. Nat Metab. 2023 Jul;5(7):1088-1100. doi: 10.1038/s42255-023-00846-3. Epub 2023 Jul 20. Nat Metab. 2023. PMID: 37488456 Free PMC article. Review.
Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis.
Douglas A, Stevens B, Rendas M, Kane H, Lynch E, Kunkemoeller B, Wessendorf-Rodriguez K, Day EA, Sutton C, Brennan M, O'Brien K, Kohlgruber AC, Prendeville H, Garza AE, O'Neill LAJ, Mills KHG, Metallo CM, Veiga-Fernandes H, Lynch L. Douglas A, et al. Nature. 2024 Dec;636(8041):206-214. doi: 10.1038/s41586-024-08131-3. Epub 2024 Oct 30. Nature. 2024. PMID: 39478228 Free PMC article.
Targeting TRPC channels for control of arthritis-induced bone erosion.
Ray S, McCall JL, Tian JB, Jeon J, Douglas A, Tyler K, Liu S, Berry K, Nicewarner B, Hall C, Groschner K, Bacsa B, Geldenhuys W, Zhu MX, Blair HC, Barnett JB, Soboloff J. Ray S, et al. Among authors: douglas a. Sci Adv. 2025 Jan 17;11(3):eabm9843. doi: 10.1126/sciadv.abm9843. Epub 2025 Jan 15. Sci Adv. 2025. PMID: 39813349 Free PMC article.
1,429 results