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Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry.
Szymczak-Kulus K, Weidler S, Bereznicka A, Mikolajczyk K, Kaczmarek R, Bednarz B, Zhang T, Urbaniak A, Olczak M, Park EY, Majorczyk E, Kapczynska K, Lukasiewicz J, Wuhrer M, Unverzagt C, Czerwinski M. Szymczak-Kulus K, et al. Among authors: mikolajczyk k. J Biol Chem. 2021 Jan-Jun;296:100299. doi: 10.1016/j.jbc.2021.100299. Epub 2021 Jan 15. J Biol Chem. 2021. PMID: 33460651 Free PMC article.
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR blood group antigens.
Kaczmarek R, Duk M, Szymczak K, Korchagina E, Tyborowska J, Mikolajczyk K, Bovin N, Szewczyk B, Jaskiewicz E, Czerwinski M. Kaczmarek R, et al. Among authors: mikolajczyk k. Biochem Biophys Res Commun. 2016 Jan 29;470(1):168-174. doi: 10.1016/j.bbrc.2016.01.017. Epub 2016 Jan 7. Biochem Biophys Res Commun. 2016. PMID: 26773500
Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system.
Kaczmarek R, Szymczak-Kulus K, Bereźnicka A, Mikołajczyk K, Duk M, Majorczyk E, Krop-Watorek A, Klausa E, Skowrońska J, Michalewska B, Brojer E, Czerwinski M. Kaczmarek R, et al. Among authors: mikolajczyk k. PLoS One. 2018 Apr 30;13(4):e0196627. doi: 10.1371/journal.pone.0196627. eCollection 2018. PLoS One. 2018. PMID: 29709005 Free PMC article.
56 results