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TR1801-ADC: a highly potent cMet antibody-drug conjugate with high activity in patient-derived xenograft models of solid tumors.
Gymnopoulos M, Betancourt O, Blot V, Fujita R, Galvan D, Lieuw V, Nguyen S, Snedden J, Stewart C, Villicana J, Wojciak J, Wong E, Pardo R, Patel N, D'Hooge F, Vijayakrishnan B, Barry C, Hartley JA, Howard PW, Newman R, Coronella J. Gymnopoulos M, et al. Mol Oncol. 2020 Jan;14(1):54-68. doi: 10.1002/1878-0261.12600. Epub 2019 Dec 3. Mol Oncol. 2020. PMID: 31736230 Free PMC article.
A novel non-agonist c-Met antibody drug conjugate with superior potency over a c-Met tyrosine kinase inhibitor in c-Met amplified and non-amplified cancers.
Fujita R, Blot V, Wong E, Stewart C, Lieuw V, Richardson R, Banah A, Villicana J, Timmer A, Coronella J, Newman R, Gymnopoulos M. Fujita R, et al. Among authors: gymnopoulos m. Cancer Biol Ther. 2020 Jun 2;21(6):549-559. doi: 10.1080/15384047.2020.1737490. Epub 2020 Mar 19. Cancer Biol Ther. 2020. PMID: 32192391 Free PMC article.
Rare cancer-specific mutations in PIK3CA show gain of function.
Gymnopoulos M, Elsliger MA, Vogt PK. Gymnopoulos M, et al. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5569-74. doi: 10.1073/pnas.0701005104. Epub 2007 Mar 21. Proc Natl Acad Sci U S A. 2007. PMID: 17376864 Free PMC article.
Cancer-specific mutations in phosphatidylinositol 3-kinase.
Vogt PK, Kang S, Elsliger MA, Gymnopoulos M. Vogt PK, et al. Among authors: gymnopoulos m. Trends Biochem Sci. 2007 Jul;32(7):342-9. doi: 10.1016/j.tibs.2007.05.005. Epub 2007 Jun 11. Trends Biochem Sci. 2007. PMID: 17561399 Review.
PI 3-kinase and cancer: changing accents.
Vogt PK, Gymnopoulos M, Hart JR. Vogt PK, et al. Among authors: gymnopoulos m. Curr Opin Genet Dev. 2009 Feb;19(1):12-7. doi: 10.1016/j.gde.2008.11.011. Curr Opin Genet Dev. 2009. PMID: 19185485 Free PMC article. Review.
Phosphatidylinositol 3-kinase: the oncoprotein.
Vogt PK, Hart JR, Gymnopoulos M, Jiang H, Kang S, Bader AG, Zhao L, Denley A. Vogt PK, et al. Among authors: gymnopoulos m. Curr Top Microbiol Immunol. 2010;347:79-104. doi: 10.1007/82_2010_80. Curr Top Microbiol Immunol. 2010. PMID: 20582532 Free PMC article. Review.
16 results