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Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model.
Bollenbach M, Nemska S, Wagner P, Camelin G, Daubeuf F, Obrecht A, Villa P, Rognan D, Bihel F, Bourguignon JJ, Schmitt M, Frossard N. Bollenbach M, et al. Among authors: villa p. Molecules. 2021 Jan 13;26(2):391. doi: 10.3390/molecules26020391. Molecules. 2021. PMID: 33450992 Free PMC article.
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Kümmerle AE, Schmitt M, Cardozo SV, Lugnier C, Villa P, Lopes AB, Romeiro NC, Justiniano H, Martins MA, Fraga CA, Bourguignon JJ, Barreiro EJ. Kümmerle AE, et al. Among authors: villa p. J Med Chem. 2012 Sep 13;55(17):7525-45. doi: 10.1021/jm300514y. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22891752
Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae).
Houël E, Fleury M, Odonne G, Nardella F, Bourdy G, Vonthron-Sénécheau C, Villa P, Obrecht A, Eparvier V, Deharo E, Stien D. Houël E, et al. Among authors: villa p. J Ethnopharmacol. 2015 May 26;166:279-85. doi: 10.1016/j.jep.2015.03.015. Epub 2015 Mar 16. J Ethnopharmacol. 2015. PMID: 25792015
Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians.
Houël E, Nardella F, Jullian V, Valentin A, Vonthron-Sénécheau C, Villa P, Obrecht A, Kaiser M, Bourreau E, Odonne G, Fleury M, Bourdy G, Eparvier V, Deharo E, Stien D. Houël E, et al. Among authors: villa p. J Ethnopharmacol. 2016 Jul 1;187:241-8. doi: 10.1016/j.jep.2016.04.053. Epub 2016 Apr 28. J Ethnopharmacol. 2016. PMID: 27132714
Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation.
Bollenbach M, Salvat E, Daubeuf F, Wagner P, Yalcin I, Humo M, Letellier B, Becker LJ, Bihel F, Bourguignon JJ, Villa P, Obrecht A, Frossard N, Barrot M, Schmitt M. Bollenbach M, et al. Among authors: villa p. Eur J Med Chem. 2018 Mar 10;147:163-182. doi: 10.1016/j.ejmech.2018.01.049. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29432948 Review.
WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.
Chen W, Zebaze LN, Dong J, Chézeau L, Inquimbert P, Hugel S, Niu S, Bihel F, Boutant E, Réal E, Villa P, Junier MP, Chneiweiss H, Hibert M, Haiech J, Kilhoffer MC, Zeniou M. Chen W, et al. Among authors: villa p. Oncotarget. 2018 Jun 5;9(43):27197-27219. doi: 10.18632/oncotarget.25509. eCollection 2018 Jun 5. Oncotarget. 2018. PMID: 29930759 Free PMC article.
Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia.
Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D, Haiech J, Knehans T, Rognan D, Heissler D, Marsol C, Villa P, Galzi JL, Hibert M, Frossard N, Bonnet D. Regenass P, et al. Among authors: villa p. J Med Chem. 2018 Sep 13;61(17):7671-7686. doi: 10.1021/acs.jmedchem.8b00657. Epub 2018 Aug 28. J Med Chem. 2018. PMID: 30106292
647 results