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Page 1
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.
Kalev P, Hyer ML, Gross S, Konteatis Z, Chen CC, Fletcher M, Lein M, Aguado-Fraile E, Frank V, Barnett A, Mandley E, Goldford J, Chen Y, Sellers K, Hayes S, Lizotte K, Quang P, Tuncay Y, Clasquin M, Peters R, Weier J, Simone E, Murtie J, Liu W, Nagaraja R, Dang L, Sui Z, Biller SA, Travins J, Marks KM, Marjon K. Kalev P, et al. Among authors: barnett a. Cancer Cell. 2021 Feb 8;39(2):209-224.e11. doi: 10.1016/j.ccell.2020.12.010. Epub 2021 Jan 14. Cancer Cell. 2021. PMID: 33450196 Free article.
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
Konteatis Z, Travins J, Gross S, Marjon K, Barnett A, Mandley E, Nicolay B, Nagaraja R, Chen Y, Sun Y, Liu Z, Yu J, Ye Z, Jiang F, Wei W, Fang C, Gao Y, Kalev P, Hyer ML, DeLaBarre B, Jin L, Padyana AK, Dang L, Murtie J, Biller SA, Sui Z, Marks KM. Konteatis Z, et al. Among authors: barnett a. J Med Chem. 2021 Apr 22;64(8):4430-4449. doi: 10.1021/acs.jmedchem.0c01895. Epub 2021 Apr 8. J Med Chem. 2021. PMID: 33829783 Free article.
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. Zabala-Letona A, et al. Among authors: barnett a. Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28. Nature. 2017. PMID: 28658205 Free PMC article.
Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. Zabala-Letona A, et al. Among authors: barnett a. Nature. 2018 Feb 22;554(7693):554. doi: 10.1038/nature25470. Epub 2018 Jan 17. Nature. 2018. PMID: 29342137
Climate-driven global redistribution of an ocean giant predicts increased threat from shipping.
Womersley FC, Sousa LL, Humphries NE, Abrantes K, Araujo G, Bach SS, Barnett A, Berumen ML, Lion SB, Braun CD, Clingham E, Cochran JEM, de la Parra R, Diamant S, Dove ADM, Duarte CM, Dudgeon CL, Erdmann MV, Espinoza E, Ferreira LC, Fitzpatrick R, Cano JG, Green JR, Guzman HM, Hardenstine R, Hasan A, Hazin FHV, Hearn AR, Hueter RE, Jaidah MY, Labaja J, Ladino F, Macena BCL, Meekan MG, Morris JJ Jr, Norman BM, Peñaherrera-Palma CR, Pierce SJ, Quintero LM, Ramírez-Macías D, Reynolds SD, Robinson DP, Rohner CA, Rowat DRL, Sequeira AMM, Sheaves M, Shivji MS, Sianipar AB, Skomal GB, Soler G, Syakurachman I, Thorrold SR, Thums M, Tyminski JP, Webb DH, Wetherbee BM, Queiroz N, Sims DW. Womersley FC, et al. Among authors: barnett a. Nat Clim Chang. 2024;14(12):1282-1291. doi: 10.1038/s41558-024-02129-5. Epub 2024 Oct 7. Nat Clim Chang. 2024. PMID: 39650805 Free PMC article.
Time Isn't your FoCUS, do cardiac POCUS!
Hunnicutt W, Barnett A, Gormley MA, Eicken J. Hunnicutt W, et al. Among authors: barnett a. Am J Emerg Med. 2024 Nov 26;88:189-191. doi: 10.1016/j.ajem.2024.11.063. Online ahead of print. Am J Emerg Med. 2024. PMID: 39647226
The costs of competition in distributing scarce research funds.
Schweiger G, Barnett A, van den Besselaar P, Bornmann L, De Block A, Ioannidis JPA, Sandström U, Conix S. Schweiger G, et al. Among authors: barnett a. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2407644121. doi: 10.1073/pnas.2407644121. Epub 2024 Dec 2. Proc Natl Acad Sci U S A. 2024. PMID: 39621909 Free PMC article.
Associations of perceived neighbourhood and home environments with sedentary behaviour among adolescents in 14 countries: the IPEN adolescent cross sectional observational study.
Anjana RM, Ranjani H, Cerin E, Akram M, Salmon J, Conway TL, Cain KL, Pradeepa R, Barnett A, Sit CHP, Van Dyck D, Hino AA, Pizarro A, Oyeyemi AL, Muda WAMW, Moran MR, Troelsen J, Mitáš J, Islam MZ, Queralt A, Mohan V, Hinckson E, Sallis JF. Anjana RM, et al. Among authors: barnett a. Int J Behav Nutr Phys Act. 2024 Nov 29;21(1):136. doi: 10.1186/s12966-024-01678-4. Int J Behav Nutr Phys Act. 2024. PMID: 39614267 Free PMC article.
iDiabetes platform-enhanced phenotyping of patients with diabetes for precision diagnosis, prognosis and treatment: study protocol for a cluster-randomised controlled study in Tayside, Scotland.
Lin Y, Leith D, Abbott M, Barrett R, Bell S, Croudace TJ, Cunningham S, Dillon J, Donnan P, Farre A, Hernández R, Lang C, McKenzie S, Mordi I, Morrow S, Munro C, Philip S, Ryan M, Wake D, Wang H, Win M, Pearson E; iDiabetes Study Team; iDiabetes Study Team. Lin Y, et al. BMJ Open. 2024 Nov 28;14(11):e086594. doi: 10.1136/bmjopen-2024-086594. BMJ Open. 2024. PMID: 39613429 Free PMC article.
1,824 results