Tomek P - Search Results

1

Towards establishing extracellular vesicle-associated RNAs as biomarkers for HER2+ breast cancer.

Hisey CL, Tomek P, Nursalim YNS, Chamley LW, Leung E. Hisey CL, et al. Among authors: tomek p. F1000Res. 2020 Nov 23;9:1362. doi: 10.12688/f1000research.27393.3. eCollection 2020. F1000Res. 2020. PMID: 33447385 Free PMC article.

2

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action.

Choi PJ, Tomek P, Tercel M, Reynisson J, Park TIH, Cooper EA, Denny WA, Jose J, Leung E. Choi PJ, et al. Among authors: tomek p. Molecules. 2022 Jan 27;27(3):880. doi: 10.3390/molecules27030880. Molecules. 2022. PMID: 35164144 Free PMC article.

3

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening.

Sari S, Tomek P, Leung E, Reynisson J. Sari S, et al. Among authors: tomek p. Molecules. 2019 Nov 28;24(23):4346. doi: 10.3390/molecules24234346. Molecules. 2019. PMID: 31795096 Free PMC article.

4

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.

Leung E, Patel J, Hollywood JA, Zafar A, Tomek P, Barker D, Pilkington LI, van Rensburg M, Langley RJ, Helsby NA, Squire CJ, Baguley BC, Denny WA, Reynisson J, Leung IKH. Leung E, et al. Among authors: tomek p. Oncol Ther. 2021 Dec;9(2):541-556. doi: 10.1007/s40487-021-00158-0. Epub 2021 Jun 23. Oncol Ther. 2021. PMID: 34159519 Free PMC article.

5

Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO.

Kim M, Tomek P. Kim M, et al. Among authors: tomek p. Front Immunol. 2021 Feb 23;12:636081. doi: 10.3389/fimmu.2021.636081. eCollection 2021. Front Immunol. 2021. PMID: 33708223 Free PMC article. Review.

6

Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.

Tomek P, Gore SK, Potts CL, Print CG, Black MA, Hallermayr A, Kilian M, Sattlegger E, Ching LM. Tomek P, et al. Cell Commun Signal. 2018 Nov 22;16(1):88. doi: 10.1186/s12964-018-0301-7. Cell Commun Signal. 2018. PMID: 30466445 Free PMC article.

7

Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2.

Tijono SM, Palmer BD, Tomek P, Flanagan JU, Henare K, Gamage S, Braun L, Ching LM. Tijono SM, et al. Among authors: tomek p. Pharmaceuticals (Basel). 2022 Aug 31;15(9):1090. doi: 10.3390/ph15091090. Pharmaceuticals (Basel). 2022. PMID: 36145311 Free PMC article.

8

Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay.

Capochiani de Iudicibus R, Tomek P, Palmer BD, Tijono SM, Flanagan JU, Ching LM. Capochiani de Iudicibus R, et al. Among authors: tomek p. Bioorg Med Chem. 2021 Jun 1;39:116160. doi: 10.1016/j.bmc.2021.116160. Epub 2021 Apr 20. Bioorg Med Chem. 2021. PMID: 33901770

9

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).

Fung SP, Wang H, Tomek P, Squire CJ, Flanagan JU, Palmer BD, Bridewell DJ, Tijono SM, Jamie JF, Ching LM. Fung SP, et al. Among authors: tomek p. Bioorg Med Chem. 2013 Dec 15;21(24):7595-603. doi: 10.1016/j.bmc.2013.10.037. Epub 2013 Nov 6. Bioorg Med Chem. 2013. PMID: 24262887

10

Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions.

Tomek P, Palmer BD, Flanagan JU, Sun C, Raven EL, Ching LM. Tomek P, et al. Eur J Med Chem. 2017 Jan 27;126:983-996. doi: 10.1016/j.ejmech.2016.12.029. Epub 2016 Dec 13. Eur J Med Chem. 2017. PMID: 28011425

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