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Page 1
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease.
Tkachev V, Kaminski J, Potter EL, Furlan SN, Yu A, Hunt DJ, McGuckin C, Zheng H, Colonna L, Gerdemann U, Carlson J, Hoffman M, Olvera J, English C, Baldessari A, Panoskaltsis-Mortari A, Watkins B, Qayed M, Suessmuth Y, Betz K, Bratrude B, Langston A, Horan JT, Ordovas-Montanes J, Shalek AK, Blazar BR, Roederer M, Kean LS. Tkachev V, et al. Sci Transl Med. 2021 Jan 13;13(576):eabc0227. doi: 10.1126/scitranslmed.abc0227. Sci Transl Med. 2021. PMID: 33441422 Free PMC article.
The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.
Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. Reichenbach DK, et al. Among authors: tkachev v. Blood. 2015 May 14;125(20):3183-92. doi: 10.1182/blood-2014-10-606830. Epub 2015 Mar 26. Blood. 2015. PMID: 25814531 Free PMC article.
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.
Furlan SN, Watkins B, Tkachev V, Flynn R, Cooley S, Ramakrishnan S, Singh K, Giver C, Hamby K, Stempora L, Garrett A, Chen J, Betz KM, Ziegler CG, Tharp GK, Bosinger SE, Promislow DE, Miller JS, Waller EK, Blazar BR, Kean LS. Furlan SN, et al. Among authors: tkachev v. Sci Transl Med. 2015 Nov 25;7(315):315ra191. doi: 10.1126/scitranslmed.aad3231. Sci Transl Med. 2015. PMID: 26606970 Free PMC article.
Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.
Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR. Saha A, et al. Among authors: tkachev v. J Clin Invest. 2016 Jul 1;126(7):2642-60. doi: 10.1172/JCI85796. Epub 2016 Jun 13. J Clin Invest. 2016. PMID: 27294527 Free PMC article.
The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.
Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS. Zheng HB, et al. Among authors: tkachev v. Am J Transplant. 2017 Mar;17(3):657-670. doi: 10.1111/ajt.14006. Epub 2016 Sep 19. Am J Transplant. 2017. PMID: 27500470 Free PMC article.
Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.
Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, Brown M, Hunt DJ, Schell JB, Zeleski K, Yu A, Giver CR, Waller EK, Miller JS, Blazar BR, Kean LS. Furlan SN, et al. Among authors: tkachev v. Blood. 2016 Nov 24;128(21):2568-2579. doi: 10.1182/blood-2016-07-726547. Epub 2016 Oct 6. Blood. 2016. PMID: 27758873 Free PMC article.
Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.
Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR. Hippen KL, et al. Among authors: tkachev v. Transplantation. 2016 Dec;100(12):2630-2639. doi: 10.1097/TP.0000000000001465. Transplantation. 2016. PMID: 27861291 Free PMC article.
Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS. Tkachev V, et al. Sci Transl Med. 2017 Sep 20;9(408):eaan3085. doi: 10.1126/scitranslmed.aan3085. Sci Transl Med. 2017. PMID: 28931653 Free PMC article.
Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.
Taraseviciute A, Tkachev V, Ponce R, Turtle CJ, Snyder JM, Liggitt HD, Myerson D, Gonzalez-Cuyar L, Baldessari A, English C, Yu A, Zheng H, Furlan SN, Hunt DJ, Hoglund V, Finney O, Brakke H, Blazar BR, Berger C, Riddell SR, Gardner R, Kean LS, Jensen MC. Taraseviciute A, et al. Among authors: tkachev v. Cancer Discov. 2018 Jun;8(6):750-763. doi: 10.1158/2159-8290.CD-17-1368. Epub 2018 Mar 21. Cancer Discov. 2018. PMID: 29563103 Free PMC article.
190 results