Heddle JG - Search Results

1

Pentapeptide repeat protein QnrB1 requires ATP hydrolysis to rejuvenate poisoned gyrase complexes.

Mazurek Ł, Ghilarov D, Michalczyk E, Pakosz Z, Metelev M, Czyszczoń W, Wawro K, Behroz I, Dubiley S, Süssmuth RD, Heddle JG. Mazurek Ł, et al. Among authors: heddle jg. Nucleic Acids Res. 2021 Feb 22;49(3):1581-1596. doi: 10.1093/nar/gkaa1266. Nucleic Acids Res. 2021. PMID: 33434265 Free PMC article.

2

Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B.

Pakosz Z, Lin TY, Michalczyk E, Nagano S, Heddle JG. Pakosz Z, et al. Among authors: heddle jg. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0026721. doi: 10.1128/AAC.00267-21. Epub 2021 Aug 2. Antimicrob Agents Chemother. 2021. PMID: 34339271 Free PMC article.

3

Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides.

Ghilarov D, Inaba-Inoue S, Stepien P, Qu F, Michalczyk E, Pakosz Z, Nomura N, Ogasawara S, Walker GC, Rebuffat S, Iwata S, Heddle JG, Beis K. Ghilarov D, et al. Among authors: heddle jg. Sci Adv. 2021 Sep 10;7(37):eabj5363. doi: 10.1126/sciadv.abj5363. Epub 2021 Sep 8. Sci Adv. 2021. PMID: 34516884 Free PMC article.

4

Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin.

Michalczyk E, Hommernick K, Behroz I, Kulike M, Pakosz-Stępień Z, Mazurek L, Seidel M, Kunert M, Santos K, von Moeller H, Loll B, Weston JB, Mainz A, Heddle JG, Süssmuth RD, Ghilarov D. Michalczyk E, et al. Among authors: heddle jg. Nat Catal. 2023;6(1):52-67. doi: 10.1038/s41929-022-00904-1. Epub 2023 Jan 23. Nat Catal. 2023. PMID: 36741192 Free PMC article.

5

Structural basis of chiral wrap and T-segment capture by Escherichia coli DNA gyrase.

Michalczyk E, Pakosz-Stępień Z, Liston JD, Gittins O, Pabis M, Heddle JG, Ghilarov D. Michalczyk E, et al. Among authors: heddle jg. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2407398121. doi: 10.1073/pnas.2407398121. Epub 2024 Nov 26. Proc Natl Acad Sci U S A. 2024. PMID: 39589884 Free PMC article.

6

In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites.

Zamble DB, Miller DA, Heddle JG, Maxwell A, Walsh CT, Hollfelder F. Zamble DB, et al. Among authors: heddle jg. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7712-7. doi: 10.1073/pnas.141225698. Epub 2001 Jun 26. Proc Natl Acad Sci U S A. 2001. PMID: 11427730 Free PMC article.

7

The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action.

Heddle JG, Barnard FM, Wentzell LM, Maxwell A. Heddle JG, et al. Nucleosides Nucleotides Nucleic Acids. 2000 Aug;19(8):1249-64. doi: 10.1080/15257770008033048. Nucleosides Nucleotides Nucleic Acids. 2000. PMID: 11097055 Review.

8

Nucleotide binding to DNA gyrase causes loss of DNA wrap.

Heddle JG, Mitelheiser S, Maxwell A, Thomson NH. Heddle JG, et al. J Mol Biol. 2004 Mar 26;337(3):597-610. doi: 10.1016/j.jmb.2004.01.049. J Mol Biol. 2004. PMID: 15019780

9

A bacteriophage mimic of the bacterial nucleoid-associated protein Fis.

Chakraborti S, Balakrishnan D, Trotter AJ, Gittens WH, Yang AWH, Jolma A, Paterson JR, Świątek S, Plewka J, Curtis FA, Bowers LY, Pålsson LO, Hughes TR, Taube M, Kozak M, Heddle JG, Sharples GJ. Chakraborti S, et al. Among authors: heddle jg. Biochem J. 2020 Apr 17;477(7):1345-1362. doi: 10.1042/BCJ20200146. Biochem J. 2020. PMID: 32207815 Free PMC article.

10

Artificial Protein Cage Delivers Active Protein Cargos to the Cell Interior.

Naskalska A, Borzęcka-Solarz K, Różycki J, Stupka I, Bochenek M, Pyza E, Heddle JG. Naskalska A, et al. Among authors: heddle jg. Biomacromolecules. 2021 Oct 11;22(10):4146-4154. doi: 10.1021/acs.biomac.1c00630. Epub 2021 Sep 9. Biomacromolecules. 2021. PMID: 34499838 Free PMC article.

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