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Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
Courade JP, Angers R, Mairet-Coello G, Pacico N, Tyson K, Lightwood D, Munro R, McMillan D, Griffin R, Baker T, Starkie D, Nan R, Westwood M, Mushikiwabo ML, Jung S, Odede G, Sweeney B, Popplewell A, Burgess G, Downey P, Citron M. Courade JP, et al. Among authors: downey p. Acta Neuropathol. 2018 Nov;136(5):729-745. doi: 10.1007/s00401-018-1911-2. Epub 2018 Sep 20. Acta Neuropathol. 2018. PMID: 30238240 Free PMC article.
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis.
Becker G, Michel A, Bahri MA, Mairet-Coello G, Lemaire C, Deprez T, Freyssin A, Jacquin L, Hustadt F, De Wolf C, Caruso M, Frequin JM, Gillent E, Bezard E, Garraux G, Luxen A, Citron M, Downey P, Plenevaux A. Becker G, et al. Among authors: downey p. Neurobiol Aging. 2021 Nov;107:142-152. doi: 10.1016/j.neurobiolaging.2021.07.012. Epub 2021 Jul 24. Neurobiol Aging. 2021. PMID: 34433125
Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain.
Mingorance-Le Meur A, Ghisdal P, Mullier B, De Ron P, Downey P, Van Der Perren C, Declercq V, Cornelis S, Famelart M, Van Asperen J, Jnoff E, Courade JP. Mingorance-Le Meur A, et al. Among authors: downey p. Br J Pharmacol. 2013 Nov;170(5):1053-63. doi: 10.1111/bph.12343. Br J Pharmacol. 2013. PMID: 23962079 Free PMC article.
234 results