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Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G. Berghoff SA, et al. Among authors: mobius w. Nat Neurosci. 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. Nat Neurosci. 2021. PMID: 33349711 Free PMC article.
High cholesterol level is essential for myelin membrane growth.
Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA. Saher G, et al. Among authors: mobius w. Nat Neurosci. 2005 Apr;8(4):468-75. doi: 10.1038/nn1426. Epub 2005 Mar 27. Nat Neurosci. 2005. PMID: 15793579
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, Orfaniotou F, Dhaunchak A, Brinkmann BG, Möbius W, Guarente L, Casaccia-Bonnefil P, Jahn O, Nave KA. Werner HB, et al. Among authors: mobius w. J Neurosci. 2007 Jul 18;27(29):7717-30. doi: 10.1523/JNEUROSCI.1254-07.2007. J Neurosci. 2007. PMID: 17634366 Free PMC article.
Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.
Goebbels S, Oltrogge JH, Kemper R, Heilmann I, Bormuth I, Wolfer S, Wichert SP, Möbius W, Liu X, Lappe-Siefke C, Rossner MJ, Groszer M, Suter U, Frahm J, Boretius S, Nave KA. Goebbels S, et al. Among authors: mobius w. J Neurosci. 2010 Jun 30;30(26):8953-64. doi: 10.1523/JNEUROSCI.0219-10.2010. J Neurosci. 2010. PMID: 20592216 Free PMC article.
257 results