Barlow N - Search Results

1

Assessing the cellular toxicity of peptide inhibitors of intracellular protein-protein interactions by microinjection.

Babu Reddiar S, Al-Wassiti H, Pouton CW, Nowell CJ, Matthews MA, Rahman A, Barlow N, Norton RS. Babu Reddiar S, et al. Among authors: barlow n. Bioorg Med Chem. 2021 Jan 1;29:115906. doi: 10.1016/j.bmc.2020.115906. Epub 2020 Dec 3. Bioorg Med Chem. 2021. PMID: 33310547

2

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Dennis ML, Chhabra S, Wang ZC, Debono A, Dolezal O, Newman J, Pitcher NP, Rahmani R, Cleary B, Barlow N, Hattarki M, Graham B, Peat TS, Baell JB, Swarbrick JD. Dennis ML, et al. Among authors: barlow n. J Med Chem. 2014 Nov 26;57(22):9612-26. doi: 10.1021/jm501417f. Epub 2014 Nov 12. J Med Chem. 2014. PMID: 25357262

3

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation.

Edgington-Mitchell LE, Barlow N, Aurelio L, Samha A, Szabo M, Graham B, Bunnett N. Edgington-Mitchell LE, et al. Among authors: barlow n. Bioorg Med Chem Lett. 2017 Jan 15;27(2):254-260. doi: 10.1016/j.bmcl.2016.11.064. Epub 2016 Nov 25. Bioorg Med Chem Lett. 2017. PMID: 27923620 Free PMC article.

4

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.

Sadek MM, Barlow N, Leung EWW, Williams-Noonan BJ, Yap BK, Shariff FM, Caradoc-Davies TT, Nicholson SE, Chalmers DK, Thompson PE, Law RHP, Norton RS. Sadek MM, et al. Among authors: barlow n. ACS Chem Biol. 2018 Oct 19;13(10):2930-2938. doi: 10.1021/acschembio.8b00561. Epub 2018 Sep 18. ACS Chem Biol. 2018. PMID: 30226743

5

Improving Membrane Permeation in the Beyond Rule-of-Five Space by Using Prodrugs to Mask Hydrogen Bond Donors.

Barlow N, Chalmers DK, Williams-Noonan BJ, Thompson PE, Norton RS. Barlow N, et al. ACS Chem Biol. 2020 Aug 21;15(8):2070-2078. doi: 10.1021/acschembio.0c00218. Epub 2020 Jul 20. ACS Chem Biol. 2020. PMID: 32628005

6

Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate.

Rahman A, Matthews MA, Nowell CJ, Chalmers DK, Thompson PE, Nicholson SE, Barlow N, Norton RS. Rahman A, et al. Among authors: barlow n. Bioorg Chem. 2022 Jun;123:105763. doi: 10.1016/j.bioorg.2022.105763. Epub 2022 Mar 26. Bioorg Chem. 2022. PMID: 35366581

7

Membrane Permeating Macrocycles: Design Guidelines from Machine Learning.

Williams-Noonan BJ, Speer MN, Le TC, Sadek MM, Thompson PE, Norton RS, Yuriev E, Barlow N, Chalmers DK, Yarovsky I. Williams-Noonan BJ, et al. Among authors: barlow n. J Chem Inf Model. 2022 Oct 10;62(19):4605-4619. doi: 10.1021/acs.jcim.2c00809. Epub 2022 Sep 30. J Chem Inf Model. 2022. PMID: 36178379

8

Targeting Melanocortin Receptors Using S_NAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.

Yue WK, Zhang T, Shandre Mugan R, Barlow N, Chalmers DK, Pouton CW, Thompson PE. Yue WK, et al. Among authors: barlow n. J Med Chem. 2023 Mar 9;66(5):3273-3283. doi: 10.1021/acs.jmedchem.2c01587. Epub 2023 Feb 21. J Med Chem. 2023. PMID: 36808973

9

Effect of linker length and composition on heterobivalent ligand-mediated receptor cross-talk between the A1 adenosine and β2 adrenergic receptors.

Barlow N, Baker SP, Scammells PJ. Barlow N, et al. ChemMedChem. 2013 Dec;8(12):2036-46. doi: 10.1002/cmdc.201300286. Epub 2013 Sep 18. ChemMedChem. 2013. PMID: 24106065

10

Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP).

Barlow N, Vanga SR, Sävmarker J, Sandström A, Burns P, Hallberg A, Åqvist J, Gutiérrez-de-Terán H, Hallberg M, Larhed M, Chai SY, Thompson PE. Barlow N, et al. RSC Med Chem. 2020 Jan 8;11(2):234-244. doi: 10.1039/c9md00485h. eCollection 2020 Feb 1. RSC Med Chem. 2020. PMID: 33479630 Free PMC article.

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