Yang L - Search Results

1

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators.

Wang S, Wang SQ, Teng QX, Yang L, Lei ZN, Yuan XH, Huo JF, Chen XB, Wang M, Yu B, Chen ZS, Liu HM. Wang S, et al. Among authors: yang l. J Med Chem. 2020 Dec 24;63(24):15979-15996. doi: 10.1021/acs.jmedchem.0c01741. Epub 2020 Dec 5. J Med Chem. 2020. PMID: 33280384

2

Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM. Chang L, et al. Among authors: yang l. Bioorg Med Chem. 2018 Oct 1;26(18):5006-5017. doi: 10.1016/j.bmc.2018.08.021. Epub 2018 Aug 18. Bioorg Med Chem. 2018. PMID: 30150104

3

Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM. Chang L, et al. Among authors: yang l. Bioorg Med Chem. 2018 Dec 1;26(22):5974-5985. doi: 10.1016/j.bmc.2018.10.027. Epub 2018 Nov 3. Bioorg Med Chem. 2018. PMID: 30401501

4

Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors.

Li ZR, Wang S, Yang L, Yuan XH, Suo FZ, Yu B, Liu HM. Li ZR, et al. Among authors: yang l. Eur J Med Chem. 2019 Mar 15;166:432-444. doi: 10.1016/j.ejmech.2019.01.075. Epub 2019 Feb 2. Eur J Med Chem. 2019. PMID: 30739825

5

Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.

Wang S, Zhao L, Shi XJ, Ding L, Yang L, Wang ZZ, Shen D, Tang K, Li XJ, Mamun M, Li H, Yu B, Zheng YC, Wang S, Liu HM. Wang S, et al. Among authors: yang l. J Med Chem. 2019 Mar 14;62(5):2772-2797. doi: 10.1021/acs.jmedchem.9b00113. Epub 2019 Mar 4. J Med Chem. 2019. PMID: 30803229

6

Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFR^L858R/T790M NSCLCs by the conformation constrained strategy.

Chen Y, Yang L, Qiao H, Cheng Z, Xie J, Zhou W, Huang X, Jiang Y, Yu B, Zhao W. Chen Y, et al. Among authors: yang l. Eur J Med Chem. 2020 Aug 1;199:112388. doi: 10.1016/j.ejmech.2020.112388. Epub 2020 May 4. Eur J Med Chem. 2020. PMID: 32402937

7

Subtle Structural Modifications Spanning from EP4 Antagonism to EP2/EP4 Dual Antagonism: A Novel Class of Thienocyclic-Based Derivatives.

Cheng Z, Zhang Y, Du L, Wang W, Chai X, He M, Zhang H, Wu D, Lu J, Zhang S, Feng B, Yang L, Liu M, Lu W. Cheng Z, et al. Among authors: yang l. J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02241. Online ahead of print. J Med Chem. 2025. PMID: 39757828

8

Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects.

Li L, Liu X, Cui Y, Chen Y, Wu H, Wang J, Gong X, Gao X, Yang L, Li J, Sun X, Mao F, Wang Y. Li L, et al. Among authors: yang l. Bioorg Chem. 2022 Oct;127:106008. doi: 10.1016/j.bioorg.2022.106008. Epub 2022 Jul 15. Bioorg Chem. 2022. PMID: 35868106 Free article.

9

Encapsulation of Flavin Cofactor within a Manganese Porphyrin-Based Metal-Organic Polyhedron for Reductive Dioxygen Activation.

Li L, Guo H, Yang L, Li X, Wang H, He C. Li L, et al. Among authors: yang l. Inorg Chem. 2020 Mar 2;59(5):2636-2640. doi: 10.1021/acs.inorgchem.9b03430. Epub 2020 Feb 14. Inorg Chem. 2020. PMID: 32058709

10

Supramolecular Catalysis of Acyl Transfer within Zinc Porphyrin-Based Metal-Organic Cages.

Li L, Yang L, Li X, Wang J, Liu X, He C. Li L, et al. Among authors: yang l. Inorg Chem. 2021 Jun 21;60(12):8802-8810. doi: 10.1021/acs.inorgchem.1c00745. Epub 2021 Jun 4. Inorg Chem. 2021. PMID: 34085514

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