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Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant.
Li X, Su J, Yang Y, Lian W, Deng Z, Yang Z, Chen G, Zhang B, Dong C, Liu X, Li L, Wang Z, Hu Z, Xu Q, Deng X. Li X, et al. Eur J Med Chem. 2020 Dec 1;207:112755. doi: 10.1016/j.ejmech.2020.112755. Epub 2020 Aug 22. Eur J Med Chem. 2020. PMID: 32882611
Enantioselective formal total synthesis of dihydrospirotryprostatin B.
Peng TF, Liu P, Guo YX, Chen MH, Tong MT, Peng DX, Yang ZT, Zhao R, Shen X, Liu JJ, Cheng FX, Shen XF. Peng TF, et al. Among authors: yang zt. J Asian Nat Prod Res. 2024 Oct;26(10):1175-1191. doi: 10.1080/10286020.2024.2355504. Epub 2024 Jun 3. J Asian Nat Prod Res. 2024. PMID: 38829012
113 results