Moran SP - Search Results

1

Tet1 Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain.

Greer CB, Wright J, Weiss JD, Lazarenko RM, Moran SP, Zhu J, Chronister KS, Jin AY, Kennedy AJ, Sweatt JD, Kaas GA. Greer CB, et al. Among authors: moran sp. J Neurosci. 2021 Jan 27;41(4):578-593. doi: 10.1523/JNEUROSCI.1821-20.2020. Epub 2020 Dec 1. J Neurosci. 2021. PMID: 33262245 Free PMC article.

2

Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M₁ PAM VU6004256.

Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK. Grannan MD, et al. Among authors: moran sp. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716. doi: 10.1021/acschemneuro.6b00230. Epub 2016 Oct 5. ACS Chem Neurosci. 2016. PMID: 27617634 Free PMC article.

3

Role of mGlu₅ Receptors and Inhibitory Neurotransmission in M₁ Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.

Ghoshal A, Moran SP, Dickerson JW, Joffe ME, Grueter BA, Xiang Z, Lindsley CW, Rook JM, Conn PJ. Ghoshal A, et al. Among authors: moran sp. ACS Chem Neurosci. 2017 Oct 18;8(10):2254-2265. doi: 10.1021/acschemneuro.7b00167. Epub 2017 Aug 9. ACS Chem Neurosci. 2017. PMID: 28679049 Free PMC article.

4

M₁ Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder.

Maksymetz J, Joffe ME, Moran SP, Stansley BJ, Li B, Temple K, Engers DW, Lawrence JJ, Lindsley CW, Conn PJ. Maksymetz J, et al. Among authors: moran sp. Biol Psychiatry. 2019 Jun 15;85(12):989-1000. doi: 10.1016/j.biopsych.2019.02.020. Epub 2019 Mar 7. Biol Psychiatry. 2019. PMID: 31003787 Free PMC article.

5

PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems.

Moran SP, Cho HP, Maksymetz J, Remke DH, Hanson RM, Niswender CM, Lindsley CW, Rook JM, Conn PJ. Moran SP, et al. ACS Chem Neurosci. 2018 Sep 19;9(9):2218-2224. doi: 10.1021/acschemneuro.8b00106. Epub 2018 Apr 25. ACS Chem Neurosci. 2018. PMID: 29683646 Free PMC article.

6

Biased M₁ receptor-positive allosteric modulators reveal role of phospholipase D in M₁-dependent rodent cortical plasticity.

Moran SP, Xiang Z, Doyle CA, Maksymetz J, Lv X, Faltin S, Fisher NM, Niswender CM, Rook JM, Lindsley CW, Conn PJ. Moran SP, et al. Sci Signal. 2019 Dec 3;12(610):eaax2057. doi: 10.1126/scisignal.aax2057. Sci Signal. 2019. PMID: 31796631 Free PMC article.

7

Discovery of VU6007496: Challenges in the Development of an M₁ Positive Allosteric Modulator Backup Candidate.

Engers JL, Bollinger KA, Capstick RA, Long MF, Bender AM, Dickerson JW, Peng W, Presley CC, Cho HP, Rodriguez AL, Niswender CM, Moran SP, Xiang Z, Blobaum AL, Boutaud O, Rook JM, Engers DW, Conn PJ, Lindsley CW. Engers JL, et al. Among authors: moran sp. ACS Chem Neurosci. 2024 Sep 18;15(18):3421-3433. doi: 10.1021/acschemneuro.4c00508. Epub 2024 Aug 28. ACS Chem Neurosci. 2024. PMID: 39197083 Free PMC article.

8

M₁-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.

Moran SP, Dickerson JW, Cho HP, Xiang Z, Maksymetz J, Remke DH, Lv X, Doyle CA, Rajan DH, Niswender CM, Engers DW, Lindsley CW, Rook JM, Conn PJ. Moran SP, et al. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771. doi: 10.1038/s41386-018-0033-9. Epub 2018 Mar 14. Neuropsychopharmacology. 2018. PMID: 29581537 Free PMC article.

9

Targeting Muscarinic Acetylcholine Receptors for the Treatment of Psychiatric and Neurological Disorders.

Moran SP, Maksymetz J, Conn PJ. Moran SP, et al. Trends Pharmacol Sci. 2019 Dec;40(12):1006-1020. doi: 10.1016/j.tips.2019.10.007. Epub 2019 Nov 8. Trends Pharmacol Sci. 2019. PMID: 31711626 Free PMC article. Review.

10

Leveraging bias to your advantage.

Moran SP, Conn PJ. Moran SP, et al. Nat Chem Biol. 2020 Mar;16(3):226-227. doi: 10.1038/s41589-020-0468-2. Nat Chem Biol. 2020. PMID: 32080631 No abstract available.

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