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Complement is activated by IgG hexamers assembled at the cell surface.
Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren PW. Diebolder CA, et al. Among authors: gros p. Science. 2014 Mar 14;343(6176):1260-3. doi: 10.1126/science.1248943. Science. 2014. PMID: 24626930 Free PMC article.
Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).
De Nardis C, Lössl P, van den Biggelaar M, Madoori PK, Leloup N, Mertens K, Heck AJ, Gros P. De Nardis C, et al. Among authors: gros p. J Biol Chem. 2017 Jan 20;292(3):912-924. doi: 10.1074/jbc.M116.758862. Epub 2016 Dec 12. J Biol Chem. 2017. PMID: 27956551 Free PMC article.
Site-specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9.
Neviani V, van Deventer S, Wörner TP, Xenaki KT, van de Waterbeemd M, Rodenburg RNP, Wortel IMN, Kuiper JK, Huisman S, Granneman J, van Bergen En Henegouwen PMP, Heck AJR, van Spriel AB, Gros P. Neviani V, et al. Among authors: gros p. FEBS J. 2020 Dec;287(24):5323-5344. doi: 10.1111/febs.15295. Epub 2020 Apr 7. FEBS J. 2020. PMID: 32181977 Free PMC article.
C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases.
Zwarthoff SA, Widmer K, Kuipers A, Strasser J, Ruyken M, Aerts PC, de Haas CJC, Ugurlar D, den Boer MA, Vidarsson G, van Strijp JAG, Gros P, Parren PWHI, van Kessel KPM, Preiner J, Beurskens FJ, Schuurman J, Ricklin D, Rooijakkers SHM. Zwarthoff SA, et al. Among authors: gros p. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2102787118. doi: 10.1073/pnas.2102787118. Proc Natl Acad Sci U S A. 2021. PMID: 34155115 Free PMC article.
782 results