Li X - Search Results

1

Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research.

Li N, Badrinarayanan A, Ishida K, Li X, Roberts J, Wang S, Hayashi M, Gupta A. Li N, et al. Among authors: li x. AAPS J. 2020 Nov 16;23(1):1. doi: 10.1208/s12248-020-00528-y. AAPS J. 2020. PMID: 33196949

2

Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes.

Li N, Badrinarayanan A, Li X, Roberts J, Hayashi M, Virk M, Gupta A. Li N, et al. Among authors: li x. Drug Metab Dispos. 2020 Oct;48(10):861-872. doi: 10.1124/dmd.120.000064. Epub 2020 Aug 5. Drug Metab Dispos. 2020. PMID: 32759366

3

P-glycoprotein Substrate Assessment in Drug Discovery: Application of Modeling to Bridge Differential Protein Expression Across In Vitro Tools.

Li N, Kulkarni P, Badrinarayanan A, Kefelegn A, Manoukian R, Li X, Prasad B, Karasu M, McCarty WJ, Knutson CG, Gupta A. Li N, et al. Among authors: li x. J Pharm Sci. 2021 Jan;110(1):325-337. doi: 10.1016/j.xphs.2020.09.017. Epub 2020 Sep 15. J Pharm Sci. 2021. PMID: 32946896

4

Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.

Huang L, Li X, Roberts J, Janosky B, Lin MH. Huang L, et al. Among authors: li x. Xenobiotica. 2015;45(6):547-55. doi: 10.3109/00498254.2014.997324. Epub 2014 Dec 24. Xenobiotica. 2015. PMID: 25539457

5

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.

Nguyen HN, Bregman H, Buchanan JL, Du B, Feric E, Huang L, Li X, Ligutti J, Liu D, Malmberg AB, Matson DJ, McDermott JS, Patel VF, Wilenkin B, Zou A, McDonough SI, Dimauro EF. Nguyen HN, et al. Among authors: li x. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1055-60. doi: 10.1016/j.bmcl.2011.11.111. Epub 2011 Dec 6. Bioorg Med Chem Lett. 2012. PMID: 22209205

6

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.

Matson DJ, Hamamoto DT, Bregman H, Cooke M, DiMauro EF, Huang L, Johnson D, Li X, McDermott J, Morgan C, Wilenkin B, Malmberg AB, McDonough SI, Simone DA. Matson DJ, et al. Among authors: li x. PLoS One. 2015 Sep 17;10(9):e0138140. doi: 10.1371/journal.pone.0138140. eCollection 2015. PLoS One. 2015. PMID: 26379236 Free PMC article.

7

The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.

Bregman H, Nguyen HN, Feric E, Ligutti J, Liu D, McDermott JS, Wilenkin B, Zou A, Huang L, Li X, McDonough SI, Dimauro EF. Bregman H, et al. Among authors: li x. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2033-42. doi: 10.1016/j.bmcl.2012.01.023. Epub 2012 Jan 18. Bioorg Med Chem Lett. 2012. PMID: 22306122

8

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Bregman H, Berry L, Buchanan JL, Chen A, Du B, Feric E, Hierl M, Huang L, Immke D, Janosky B, Johnson D, Li X, Ligutti J, Liu D, Malmberg A, Matson D, McDermott J, Miu P, Nguyen HN, Patel VF, Waldon D, Wilenkin B, Zheng XM, Zou A, McDonough SI, DiMauro EF. Bregman H, et al. Among authors: li x. J Med Chem. 2011 Jul 14;54(13):4427-45. doi: 10.1021/jm200018k. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21634377

9

Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.

Marx IE, DiMauro EF, Cheng A, Emkey R, Hitchcock SA, Huang L, Huang MY, Human J, Lee JH, Li X, Martin MW, White RD, Fremeau RT Jr, Patel VF. Marx IE, et al. Among authors: li x. Bioorg Med Chem Lett. 2009 Jan 1;19(1):31-5. doi: 10.1016/j.bmcl.2008.11.026. Epub 2008 Nov 13. Bioorg Med Chem Lett. 2009. PMID: 19062274

10

Association Between Diurnal Temperature Range and Risk of Cardiomyopathy-Induced Hospitalisation in Henan, China: A Time-Series Study.

Zhang Z, Wang Y, Zhou Y, Pei J, Zhao G, Dong P, Yang K, Liu H, Xie N, Li X, Zang X, Lin F, Chen Z. Zhang Z, et al. Among authors: li x. Risk Manag Healthc Policy. 2025 Jan 21;18:279-290. doi: 10.2147/RMHP.S502132. eCollection 2025. Risk Manag Healthc Policy. 2025. PMID: 39867988 Free PMC article.

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