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Procollagen-lysine 2-oxoglutarate 5-dioxygenases are responsible for 5R-hydroxylysine modification of therapeutic T-cell bispecific monoclonal antibodies produced by Chinese hamster ovary cells.
Bauer N, Boettger M, Papadaki S, Leitner T, Klostermann S, Kettenberger H, Georges G, Larraillet V, Gluhacevic von Kruechten D, Hillringhaus L, Vogt A, Ausländer S, Popp O. Bauer N, et al. Among authors: klostermann s. Front Bioeng Biotechnol. 2024 Oct 28;12:1414408. doi: 10.3389/fbioe.2024.1414408. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 39530057 Free PMC article.
Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity.
Ros F, Offner S, Klostermann S, Thorey I, Niersbach H, Breuer S, Zarnt G, Lorenz S, Puels J, Siewe B, Schueler N, Dragicevic T, Ostler D, Hansen-Wester I, Lifke V, Kaluza B, Kaluza K, van Schooten W, Buelow R, Tissot AC, Platzer J. Ros F, et al. Among authors: klostermann s. MAbs. 2020 Jan-Dec;12(1):1846900. doi: 10.1080/19420862.2020.1846900. MAbs. 2020. PMID: 33228444 Free PMC article.
Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics.
Tyshchuk O, Gstöttner C, Funk D, Nicolardi S, Frost S, Klostermann S, Becker T, Jolkver E, Schumacher F, Koller CF, Völger HR, Wuhrer M, Bulau P, Mølhøj M. Tyshchuk O, et al. Among authors: klostermann s. MAbs. 2019 Oct;11(7):1219-1232. doi: 10.1080/19420862.2019.1635865. Epub 2019 Jul 24. MAbs. 2019. PMID: 31339437 Free PMC article.
45 results