Jacobs RQ - Search Results

1

Defining the divergent enzymatic properties of RNA polymerases I and II.

Jacobs RQ, Ingram ZM, Lucius AL, Schneider DA. Jacobs RQ, et al. J Biol Chem. 2021 Jan-Jun;296:100051. doi: 10.1074/jbc.RA120.015904. Epub 2020 Nov 24. J Biol Chem. 2021. PMID: 33168625 Free PMC article.

2

The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro.

Jacobs RQ, Huffines AK, Laiho M, Schneider DA. Jacobs RQ, et al. J Biol Chem. 2022 Jan;298(1):101450. doi: 10.1016/j.jbc.2021.101450. Epub 2021 Nov 25. J Biol Chem. 2022. PMID: 34838819 Free PMC article.

3

Uncovering the mechanisms of transcription elongation by eukaryotic RNA polymerases I, II, and III.

Jacobs RQ, Carter ZI, Lucius AL, Schneider DA. Jacobs RQ, et al. iScience. 2022 Oct 8;25(11):105306. doi: 10.1016/j.isci.2022.105306. eCollection 2022 Nov 18. iScience. 2022. PMID: 36304104 Free PMC article.

4

RNA Polymerase I Is Uniquely Vulnerable to the Small-Molecule Inhibitor BMH-21.

Jacobs RQ, Fuller KB, Cooper SL, Carter ZI, Laiho M, Lucius AL, Schneider DA. Jacobs RQ, et al. Cancers (Basel). 2022 Nov 11;14(22):5544. doi: 10.3390/cancers14225544. Cancers (Basel). 2022. PMID: 36428638 Free PMC article.

5

Transient-State Kinetic Analysis of the RNA Polymerase II Nucleotide Incorporation Mechanism.

Carter ZI, Jacobs RQ, Schneider DA, Lucius AL. Carter ZI, et al. Among authors: jacobs rq. Biochemistry. 2023 Jan 3;62(1):95-108. doi: 10.1021/acs.biochem.2c00608. Epub 2022 Dec 16. Biochemistry. 2023. PMID: 36525636 Free PMC article.

6

Protocol for monitoring and analyzing single nucleotide incorporation by S. cerevisiae RNA polymerases.

Jacobs RQ, Bellis NF, Lucius AL, Schneider DA. Jacobs RQ, et al. STAR Protoc. 2023 Mar 24;4(2):102191. doi: 10.1016/j.xpro.2023.102191. Online ahead of print. STAR Protoc. 2023. PMID: 36964908 Free PMC article.

7

The A12.2 Subunit Plays an Integral Role in Pyrophosphate Release of RNA Polymerase I.

Fuller KB, Jacobs RQ, Schneider DA, Lucius AL. Fuller KB, et al. Among authors: jacobs rq. J Mol Biol. 2023 Aug 1;435(15):168186. doi: 10.1016/j.jmb.2023.168186. Epub 2023 Jun 22. J Mol Biol. 2023. PMID: 37355033 Free PMC article.

8

Transcription elongation mechanisms of RNA polymerases I, II, and III and their therapeutic implications.

Jacobs RQ, Schneider DA. Jacobs RQ, et al. J Biol Chem. 2024 Mar;300(3):105737. doi: 10.1016/j.jbc.2024.105737. Epub 2024 Feb 8. J Biol Chem. 2024. PMID: 38336292 Free PMC article. Review.

9

Reversible Kinetics in Multi-nucleotide Addition Catalyzed by S. cerevisiae RNA polymerase II Reveal Slow Pyrophosphate Release.

Fuller KB, Jacobs RQ, Schneider DA, Lucius AL. Fuller KB, et al. Among authors: jacobs rq. J Mol Biol. 2024 Jun 15;436(12):168606. doi: 10.1016/j.jmb.2024.168606. Epub 2024 May 8. J Mol Biol. 2024. PMID: 38729258

10

Global kinetic mechanism describing single nucleotide incorporation for RNA polymerase I reveals fast UMP incorporation.

Fuller KB, Jacobs RQ, Carter ZI, Cuny ZG, Schneider DA, Lucius AL. Fuller KB, et al. Among authors: jacobs rq. Biophys Chem. 2024 Sep;312:107281. doi: 10.1016/j.bpc.2024.107281. Epub 2024 Jun 8. Biophys Chem. 2024. PMID: 38889653

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