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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.
Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ. Odle RI, et al. Mol Cell. 2020 Jan 16;77(2):228-240.e7. doi: 10.1016/j.molcel.2019.10.016. Epub 2019 Nov 13. Mol Cell. 2020. PMID: 31733992 Free PMC article.
Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.
Machin PA, Johnsson AE, Massey EJ, Pantarelli C, Chetwynd SA, Chu JY, Okkenhaug H, Segonds-Pichon A, Walker S, Malliri A, Fukui Y, Welch HCE. Machin PA, et al. Among authors: walker s. Front Immunol. 2023 Jun 13;14:1180886. doi: 10.3389/fimmu.2023.1180886. eCollection 2023. Front Immunol. 2023. PMID: 37383235 Free PMC article.
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.
Chessa TAM, Jung P, Anwar A, Suire S, Anderson KE, Barneda D, Kielkowska A, Sadiq BA, Lai IW, Felisbino S, Turnham DJ, Pearson HB, Phillips WA, Sasaki J, Sasaki T, Oxley D, Spensberger D, Segonds-Pichon A, Wilson M, Walker S, Okkenhaug H, Cosulich S, Hawkins PT, Stephens LR. Chessa TAM, et al. Among authors: walker s. Mol Cell. 2023 Aug 17;83(16):2991-3009.e13. doi: 10.1016/j.molcel.2023.07.015. Epub 2023 Aug 10. Mol Cell. 2023. PMID: 37567175 Free article.
The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.
Hornigold K, Baker MJ, Machin PA, Chetwynd SA, Johnsson AK, Pantarelli C, Islam P, Stammers M, Crossland L, Oxley D, Okkenhaug H, Walker S, Walker R, Segonds-Pichon A, Fukui Y, Malliri A, Welch HCE. Hornigold K, et al. Among authors: walker s, walker r. Front Immunol. 2023 Nov 21;14:1223653. doi: 10.3389/fimmu.2023.1223653. eCollection 2023. Front Immunol. 2023. PMID: 38077328 Free PMC article.
A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation.
Bertran MT, Walmsley R, Cummings T, Aramburu IV, Benton DJ, Mora Molina R, Assalaarachchi J, Chasampalioti M, Swanton T, Joshi D, Federico S, Okkenhaug H, Yu L, Oxley D, Walker S, Papayannopoulos V, Suga H, Christophorou MA, Walport LJ. Bertran MT, et al. Among authors: walker s. Nat Commun. 2024 Nov 11;15(1):9746. doi: 10.1038/s41467-024-53554-1. Nat Commun. 2024. PMID: 39528459 Free PMC article.
The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues.
Johnsson AE, Dai Y, Nobis M, Baker MJ, McGhee EJ, Walker S, Schwarz JP, Kadir S, Morton JP, Myant KB, Huels DJ, Segonds-Pichon A, Sansom OJ, Anderson KI, Timpson P, Welch HCE. Johnsson AE, et al. Among authors: walker s. Cell Rep. 2014 Mar 27;6(6):1153-1164. doi: 10.1016/j.celrep.2014.02.024. Epub 2014 Mar 13. Cell Rep. 2014. PMID: 24630994 Free PMC article.
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
Ferguson GJ, Milne L, Kulkarni S, Sasaki T, Walker S, Andrews S, Crabbe T, Finan P, Jones G, Jackson S, Camps M, Rommel C, Wymann M, Hirsch E, Hawkins P, Stephens L. Ferguson GJ, et al. Among authors: walker s. Nat Cell Biol. 2007 Jan;9(1):86-91. doi: 10.1038/ncb1517. Epub 2006 Dec 17. Nat Cell Biol. 2007. PMID: 17173040
5,523 results