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Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
Biochem J. 2020 Nov 27;477(22):4425-4441. doi: 10.1042/BCJ20200656.
Biochem J. 2020.
PMID: 33141153
Free PMC article.
The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction.
Fernandes PM, Kinkead J, McNae IW, Bringaud F, Michels PAM, Walkinshaw MD.
Fernandes PM, et al. Among authors: kinkead j.
Biochem J. 2019 Jan 18;476(2):179-191. doi: 10.1042/BCJ20180635.
Biochem J. 2019.
PMID: 30404924
Free PMC article.
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Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
McNae IW, Kinkead J, Malik D, Yen LH, Walker MK, Swain C, Webster SP, Gray N, Fernandes PM, Myburgh E, Blackburn EA, Ritchie R, Austin C, Wear MA, Highton AJ, Keats AJ, Vong A, Dornan J, Mottram JC, Michels PAM, Pettit S, Walkinshaw MD.
McNae IW, et al. Among authors: kinkead j.
Nat Commun. 2021 Feb 16;12(1):1052. doi: 10.1038/s41467-021-21273-6.
Nat Commun. 2021.
PMID: 33594070
Free PMC article.
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Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis.
Fernandes PM, Kinkead J, McNae IW, Vásquez-Valdivieso M, Wear MA, Michels PAM, Walkinshaw MD.
Fernandes PM, et al. Among authors: kinkead j.
FEBS J. 2020 Jul;287(13):2847-2861. doi: 10.1111/febs.15177. Epub 2020 Jan 8.
FEBS J. 2020.
PMID: 31838765
Free PMC article.
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