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Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.
Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Clément K, et al. Among authors: gordon g. Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. Epub 2020 Oct 30. Lancet Diabetes Endocrinol. 2020. PMID: 33137293 Clinical Trial.
Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial.
Verma S, Dhingra NK, Butler J, Anker SD, Ferreira JP, Filippatos G, Januzzi JL, Lam CSP, Sattar N, Peil B, Nordaby M, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Reduced trial committees and investigators. Verma S, et al. Lancet Diabetes Endocrinol. 2022 Jan;10(1):35-45. doi: 10.1016/S2213-8587(21)00292-8. Epub 2021 Nov 30. Lancet Diabetes Endocrinol. 2022. PMID: 34861154
Design of CONQUEST, a novel, randomized, placebo-controlled, Phase 2b platform clinical trial to investigate new treatments for patients with early active systemic sclerosis with interstitial lung disease.
Khanna D, Evnin LB, Assassi S, Benton WW, Gordon G, Maslova K, Steffgen J, Maher TM. Khanna D, et al. Among authors: gordon g. J Scleroderma Relat Disord. 2024 Nov 5:23971983241278079. doi: 10.1177/23971983241278079. Online ahead of print. J Scleroderma Relat Disord. 2024. PMID: 39544897 Free PMC article.
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC; COMET Consortium; DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR. Spottiswoode N, et al. Nat Commun. 2024 Oct 29;15(1):9339. doi: 10.1038/s41467-024-53566-x. Nat Commun. 2024. PMID: 39472555 Free PMC article.
Assessment of combined α-GAL enzyme activity and lyso-GL3 for Fabry disease screening in women with chronic kidney disease.
Silva CAB, de Carvalho Barreto F, Neto OMV, Lucca LJ, Vieira FA, Gueiros APS, Boger MV, Silva AQ, Guedes FL, Israel KCP, Gordon GEM, Veloso VSP, Sevignani G, Barretto CT, Rosa MG, Pascotto RC, Ennes GS, da Silva Montenegro Malaguti Souza EM, Ribeiro MG, de Andrade LGM. Silva CAB, et al. Among authors: gordon gem. Mol Genet Metab. 2024 Sep-Oct;143(1-2):108565. doi: 10.1016/j.ymgme.2024.108565. Epub 2024 Aug 16. Mol Genet Metab. 2024. PMID: 39182416 Free article.
Primary cilia signaling in astrocytes mediates development and regional-specific functional specification.
Wang L, Guo Q, Acharya S, Zheng X, Huynh V, Whitmore B, Yimit A, Malhotra M, Chatterji S, Rosin N, Labit E, Chipak C, Gorzo K, Haidey J, Elliott DA, Ram T, Zhang Q, Kuipers H, Gordon G, Biernaskie J, Guo J. Wang L, et al. Among authors: gordon g. Nat Neurosci. 2024 Sep;27(9):1708-1720. doi: 10.1038/s41593-024-01726-z. Epub 2024 Aug 5. Nat Neurosci. 2024. PMID: 39103557
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Neyton LPA, Patel RK, Sarma A; UCSF COMET Consortium; Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK. Neyton LPA, et al. Nat Commun. 2024 Jun 28;15(1):5483. doi: 10.1038/s41467-024-49756-2. Nat Commun. 2024. PMID: 38942804 Free PMC article.
1,121 results