Chennamsetty N - Search Results

1

Impact of virus-antibody interactions on viral clearance in anion exchange chromatography.

Hung J, Lam SF, Tan Z, Choy D, Chennamsetty N, Lewandowski A, Qi W, Lynch M, Ghose S, Li ZJ. Hung J, et al. Among authors: chennamsetty n. J Chromatogr A. 2020 Dec 6;1633:461635. doi: 10.1016/j.chroma.2020.461635. Epub 2020 Oct 22. J Chromatogr A. 2020. PMID: 33128974

2

Insights in understanding aggregate formation and dissociation in cation exchange chromatography for a structurally unstable Fc-fusion protein.

Chen Z, Huang C, Chennamsetty N, Xu X, Li ZJ. Chen Z, et al. Among authors: chennamsetty n. J Chromatogr A. 2016 Aug 19;1460:110-22. doi: 10.1016/j.chroma.2016.07.023. Epub 2016 Jul 9. J Chromatogr A. 2016. PMID: 27452990

3

Assessing detergent-mediated virus inactivation, protein stability, and impurity clearance in biologics downstream processes.

Feroz H, Chennamsetty N, Byers S, Holstein M, Li ZJ, Ghose S. Feroz H, et al. Among authors: chennamsetty n. Biotechnol Bioeng. 2022 Apr;119(4):1091-1104. doi: 10.1002/bit.28034. Epub 2022 Feb 8. Biotechnol Bioeng. 2022. PMID: 35023152

4

Streamlining the polishing step development process via physicochemical characterization of monoclonal antibody aggregates.

Doss HR, Raman M, Knihtila R, Chennamsetty N, Wang D, Shupe A, Mussa N. Doss HR, et al. Among authors: chennamsetty n. J Chromatogr A. 2019 Aug 2;1598:101-112. doi: 10.1016/j.chroma.2019.03.044. Epub 2019 Mar 22. J Chromatogr A. 2019. PMID: 30954243

5

Purity Determination by Capillary Electrophoresis Sodium Hexadecyl Sulfate (CE-SHS): A Novel Application For Therapeutic Protein Characterization.

Beckman J, Song Y, Gu Y, Voronov S, Chennamsetty N, Krystek S, Mussa N, Li ZJ. Beckman J, et al. Among authors: chennamsetty n. Anal Chem. 2018 Feb 20;90(4):2542-2547. doi: 10.1021/acs.analchem.7b03831. Epub 2018 Feb 5. Anal Chem. 2018. PMID: 29357216

6

Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb.

Lan W, Valente JJ, Ilott A, Chennamsetty N, Liu Z, Rizzo JM, Yamniuk AP, Qiu D, Shackman HM, Bolgar MS. Lan W, et al. Among authors: chennamsetty n. MAbs. 2020 Jan-Dec;12(1):1763138. doi: 10.1080/19420862.2020.1763138. MAbs. 2020. PMID: 32432964 Free PMC article.

7

Probing the Tryptophan Environment in Therapeutic Proteins: Implications for Higher Order Structure on Tryptophan Oxidation.

Barnett GV, Balakrishnan G, Chennamsetty N, Hoffman L, Bongers J, Tao L, Huang Y, Slaney T, Das TK, Leone A, Kar SR. Barnett GV, et al. Among authors: chennamsetty n. J Pharm Sci. 2019 Jun;108(6):1944-1952. doi: 10.1016/j.xphs.2018.12.027. Epub 2019 Jan 11. J Pharm Sci. 2019. PMID: 30639740

8

Cyclization of N-Terminal Glutamic Acid to pyro-Glutamic Acid Impacts Monoclonal Antibody Charge Heterogeneity Despite Its Appearance as a Neutral Transformation.

Liu Z, Valente J, Lin S, Chennamsetty N, Qiu D, Bolgar M. Liu Z, et al. Among authors: chennamsetty n. J Pharm Sci. 2019 Oct;108(10):3194-3200. doi: 10.1016/j.xphs.2019.05.023. Epub 2019 May 27. J Pharm Sci. 2019. PMID: 31145921

9

Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies.

Kayser V, Chennamsetty N, Voynov V, Forrer K, Helk B, Trout BL. Kayser V, et al. Among authors: chennamsetty n. Biotechnol J. 2011 Jan;6(1):38-44. doi: 10.1002/biot.201000091. Biotechnol J. 2011. PMID: 20949542

10

Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding.

Kayser V, Chennamsetty N, Voynov V, Helk B, Trout BL. Kayser V, et al. Among authors: chennamsetty n. MAbs. 2011 Jul-Aug;3(4):408-11. doi: 10.4161/mabs.3.4.15677. Epub 2011 Jul 1. MAbs. 2011. PMID: 21540645 Free PMC article.

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