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Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.
Quevedo CE, Bataille CJR, Byrne S, Durbin M, Elkins J, Guillermo A, Jones AM, Knapp S, Nadali A, Walker RG, Wilkinson IVL, Wynne GM, Davies SG, Russell AJ. Quevedo CE, et al. Among authors: elkins j. Bioorg Med Chem. 2020 Nov 15;28(22):115724. doi: 10.1016/j.bmc.2020.115724. Epub 2020 Aug 26. Bioorg Med Chem. 2020. PMID: 33128909
Structure of dystrophia myotonica protein kinase.
Elkins JM, Amos A, Niesen FH, Pike AC, Fedorov O, Knapp S. Elkins JM, et al. Protein Sci. 2009 Apr;18(4):782-91. doi: 10.1002/pro.82. Protein Sci. 2009. PMID: 19309729 Free PMC article.
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L. Tahtouh T, et al. J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998443
Structural insights into the activation of MST3 by MO25.
Mehellou Y, Alessi DR, Macartney TJ, Szklarz M, Knapp S, Elkins JM. Mehellou Y, et al. Among authors: elkins jm. Biochem Biophys Res Commun. 2013 Feb 15;431(3):604-9. doi: 10.1016/j.bbrc.2012.12.113. Epub 2013 Jan 4. Biochem Biophys Res Commun. 2013. PMID: 23296203 Free PMC article.
363 results