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Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Jadhav VS, Lin PBC, Pennington T, Di Prisco GV, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Jadhav VS, et al. Among authors: pennington t. Mol Neurodegener. 2020 Oct 28;15(1):62. doi: 10.1186/s13024-020-00409-0. Mol Neurodegener. 2020. PMID: 33115519 Free PMC article.
Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy.
Cisternas P, Taylor X, Perkins A, Maldonado O, Allman E, Cordova R, Marambio Y, Munoz B, Pennington T, Xiang S, Zhang J, Vidal R, Atwood B, Lasagna-Reeves CA. Cisternas P, et al. Among authors: pennington t. Aging Cell. 2020 Oct;19(10):e13233. doi: 10.1111/acel.13233. Epub 2020 Sep 10. Aging Cell. 2020. PMID: 32914559 Free PMC article.
Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis.
Karahan H, Smith DC, Kim B, Dabin LC, Al-Amin MM, Wijeratne HRS, Pennington T, Viana di Prisco G, McCord B, Lin PB, Li Y, Peng J, Oblak AL, Chu S, Atwood BK, Kim J. Karahan H, et al. Among authors: pennington t. Sci Adv. 2021 Nov 5;7(45):eabe3954. doi: 10.1126/sciadv.abe3954. Epub 2021 Nov 3. Sci Adv. 2021. PMID: 34731000 Free PMC article.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE. Moutinho M, et al. Among authors: pennington t. Genome Med. 2023 Feb 20;15(1):11. doi: 10.1186/s13073-023-01160-z. Genome Med. 2023. PMID: 36805764 Free PMC article.
193 results