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Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models.
Morrish E, Copeland A, Moujalled DM, Powell JA, Silke N, Lin A, Jarman KE, Sandow JJ, Ebert G, Mackiewicz L, Beach JA, Christie EL, Lewis AC, Pomilio G, Fischer KC, MacPherson L, Bowtell DDL, Webb AI, Pellegrini M, Dawson MA, Pitson SM, Wei AH, Silke J, Brumatti G. Morrish E, et al. Among authors: fischer kc. Blood Adv. 2020 Oct 27;4(20):5062-5077. doi: 10.1182/bloodadvances.2020001576. Blood Adv. 2020. PMID: 33080008 Free PMC article.
Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers.
Diepstraten ST, Yuan Y, La Marca JE, Young S, Chang C, Whelan L, Ross AM, Fischer KC, Pomilio G, Morris R, Georgiou A, Litalien V, Brown FC, Roberts AW, Strasser A, Wei AH, Kelly GL. Diepstraten ST, et al. Among authors: fischer kc. Cancer Cell. 2024 May 13;42(5):850-868.e9. doi: 10.1016/j.ccell.2024.04.004. Epub 2024 Apr 25. Cancer Cell. 2024. PMID: 38670091 Free article.
A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.
Subas Satish HP, Iyer S, Shi MX, Wong AW, Fischer KC, Wardak AZ, Lio D, Brouwer JM, Uren RT, Czabotar PE, Miller MS, Kluck RM. Subas Satish HP, et al. Among authors: fischer kc. Cell Death Differ. 2024 Jun;31(6):711-721. doi: 10.1038/s41418-024-01289-3. Epub 2024 Apr 6. Cell Death Differ. 2024. PMID: 38582955 Free PMC article.
43 results