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Fenfluramine HCl (Fintepla® ) provides long-term clinically meaningful reduction in seizure frequency: Analysis of an ongoing open-label extension study.
Sullivan J, Scheffer IE, Lagae L, Nabbout R, Pringsheim M, Talwar D, Polster T, Galer B, Lock M, Agarwal A, Gammaitoni A, Morrison G, Farfel G. Sullivan J, et al. Among authors: farfel g. Epilepsia. 2020 Nov;61(11):2396-2404. doi: 10.1111/epi.16722. Epub 2020 Oct 19. Epilepsia. 2020. PMID: 33078386 Free PMC article. Clinical Trial.
A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects
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Boyd B, Smith S, Gammaitoni A, Galer BS, Farfel GM. Boyd B, et al. Int J Clin Pharmacol Ther. 2019 Jan;57(1):11-19. doi: 10.5414/CP203276. Int J Clin Pharmacol Ther. 2019. PMID: 30336805 Free PMC article. Clinical Trial.
Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial.
Nabbout R, Mistry A, Zuberi S, Villeneuve N, Gil-Nagel A, Sanchez-Carpintero R, Stephani U, Laux L, Wirrell E, Knupp K, Chiron C, Farfel G, Galer BS, Morrison G, Lock M, Agarwal A, Auvin S; FAiRE, DS Study Group. Nabbout R, et al. Among authors: farfel g. JAMA Neurol. 2020 Mar 1;77(3):300-308. doi: 10.1001/jamaneurol.2019.4113. JAMA Neurol. 2020. PMID: 31790543 Free PMC article. Clinical Trial.
Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial.
Lagae L, Sullivan J, Knupp K, Laux L, Polster T, Nikanorova M, Devinsky O, Cross JH, Guerrini R, Talwar D, Miller I, Farfel G, Galer BS, Gammaitoni A, Mistry A, Morrison G, Lock M, Agarwal A, Lai WW, Ceulemans B; FAiRE DS Study Group. Lagae L, et al. Among authors: farfel g. Lancet. 2019 Dec 21;394(10216):2243-2254. doi: 10.1016/S0140-6736(19)32500-0. Epub 2019 Dec 17. Lancet. 2019. PMID: 31862249 Clinical Trial.
Fenfluramine acts as a positive modulator of sigma-1 receptors.
Martin P, de Witte PAM, Maurice T, Gammaitoni A, Farfel G, Galer B. Martin P, et al. Among authors: farfel g. Epilepsy Behav. 2020 Apr;105:106989. doi: 10.1016/j.yebeh.2020.106989. Epub 2020 Mar 10. Epilepsy Behav. 2020. PMID: 32169824 Free article.
Improved everyday executive functioning following profound reduction in seizure frequency with fenfluramine: Analysis from a phase 3 long-term extension study in children/young adults with Dravet syndrome.
Bishop KI, Isquith PK, Gioia GA, Gammaitoni AR, Farfel G, Galer BS, Nabbout R, Wirrell EC, Polster T, Sullivan J. Bishop KI, et al. Among authors: farfel g. Epilepsy Behav. 2021 Aug;121(Pt A):108024. doi: 10.1016/j.yebeh.2021.108024. Epub 2021 May 20. Epilepsy Behav. 2021. PMID: 34023810 Free article. Clinical Trial.
Treatment with fenfluramine in patients with Dravet syndrome has no long-term effects on weight and growth.
Gil-Nagel A, Sullivan J, Ceulemans B, Wirrell E, Devinsky O, Nabbout R, Knupp KG, Scott Perry M, Polster T, Davis R, Lock M, Cortes RM, Gammaiton AR, Farfel G, Galer BS, Agarwal A. Gil-Nagel A, et al. Among authors: farfel g. Epilepsy Behav. 2021 Sep;122:108212. doi: 10.1016/j.yebeh.2021.108212. Epub 2021 Aug 2. Epilepsy Behav. 2021. PMID: 34352670 Free article.
Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial.
Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Knupp KG, et al. Among authors: farfel gm. JAMA Neurol. 2022 Jun 1;79(6):554-564. doi: 10.1001/jamaneurol.2022.0829. JAMA Neurol. 2022. PMID: 35499850 Free PMC article. Clinical Trial.
28 results