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Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance.
Lin HB, Naito K, Oh Y, Farber G, Kanaan G, Valaperti A, Dawood F, Zhang L, Li GH, Smyth D, Moon M, Liu Y, Liang W, Rotstein B, Philpott DJ, Kim KH, Harper ME, Liu PP. Lin HB, et al. Among authors: philpott dj. Circulation. 2020 Dec 8;142(23):2240-2258. doi: 10.1161/CIRCULATIONAHA.119.041213. Epub 2020 Oct 19. Circulation. 2020. PMID: 33070627 Free article.
NOD1 activators link innate immunity to insulin resistance.
Schertzer JD, Tamrakar AK, Magalhães JG, Pereira S, Bilan PJ, Fullerton MD, Liu Z, Steinberg GR, Giacca A, Philpott DJ, Klip A. Schertzer JD, et al. Among authors: philpott dj. Diabetes. 2011 Sep;60(9):2206-15. doi: 10.2337/db11-0004. Epub 2011 Jun 29. Diabetes. 2011. PMID: 21715553 Free PMC article.
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.
Irving AT, Mimuro H, Kufer TA, Lo C, Wheeler R, Turner LJ, Thomas BJ, Malosse C, Gantier MP, Casillas LN, Votta BJ, Bertin J, Boneca IG, Sasakawa C, Philpott DJ, Ferrero RL, Kaparakis-Liaskos M. Irving AT, et al. Among authors: philpott dj. Cell Host Microbe. 2014 May 14;15(5):623-35. doi: 10.1016/j.chom.2014.04.001. Epub 2014 Apr 17. Cell Host Microbe. 2014. PMID: 24746552 Free article.
NOD1 and NOD2 in inflammation, immunity and disease.
Mukherjee T, Hovingh ES, Foerster EG, Abdel-Nour M, Philpott DJ, Girardin SE. Mukherjee T, et al. Among authors: philpott dj. Arch Biochem Biophys. 2019 Jul 30;670:69-81. doi: 10.1016/j.abb.2018.12.022. Epub 2018 Dec 19. Arch Biochem Biophys. 2019. PMID: 30578751 Review.
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE. Abdel-Nour M, et al. Among authors: philpott dj. Science. 2019 Jul 5;365(6448):eaaw4144. doi: 10.1126/science.aaw4144. Science. 2019. PMID: 31273097 Free PMC article.
244 results