Aguayo-Ortiz R - Search Results

1

Dynamics-Driven Allostery Underlies Ca²⁺-Mediated Release of SERCA Inhibition by Phospholamban.

Raguimova ON, Aguayo-Ortiz R, Robia SL, Espinoza-Fonseca LM. Raguimova ON, et al. Biophys J. 2020 Nov 3;119(9):1917-1926. doi: 10.1016/j.bpj.2020.09.014. Epub 2020 Sep 24. Biophys J. 2020. PMID: 33069270 Free PMC article.

2

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.

Aguayo-Ortiz R, Espinoza-Fonseca LM. Aguayo-Ortiz R, et al. Int J Mol Sci. 2020 Jun 10;21(11):4146. doi: 10.3390/ijms21114146. Int J Mol Sci. 2020. PMID: 32532023 Free PMC article. Review.

3

Atomistic Structure and Dynamics of the Ca²⁺-ATPase Bound to Phosphorylated Phospholamban.

Aguayo-Ortiz R, Espinoza-Fonseca LM. Aguayo-Ortiz R, et al. Int J Mol Sci. 2020 Oct 1;21(19):7261. doi: 10.3390/ijms21197261. Int J Mol Sci. 2020. PMID: 33019581 Free PMC article.

4

Conserved Luminal C-Terminal Domain Dynamically Controls Interdomain Communication in Sarcolipin.

Aguayo-Ortiz R, Fernández-de Gortari E, Espinoza-Fonseca LM. Aguayo-Ortiz R, et al. J Chem Inf Model. 2020 Aug 24;60(8):3985-3991. doi: 10.1021/acs.jcim.0c00418. Epub 2020 Jul 27. J Chem Inf Model. 2020. PMID: 32668157 Free PMC article.

5

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA.

Fisher ME, Bovo E, Aguayo-Ortiz R, Cho EE, Pribadi MP, Dalton MP, Rathod N, Lemieux MJ, Espinoza-Fonseca LM, Robia SL, Zima AV, Young HS. Fisher ME, et al. Elife. 2021 Jun 2;10:e65545. doi: 10.7554/eLife.65545. Elife. 2021. PMID: 34075877 Free PMC article.

6

Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA.

Bak JJ, Aguayo-Ortiz R, Rathod N, Primeau JO, Khan MB, Robia SL, Lemieux MJ, Espinoza-Fonseca LM, Young HS. Bak JJ, et al. Biochemistry. 2022 Jul 19;61(14):1419-1430. doi: 10.1021/acs.biochem.2c00246. Epub 2022 Jun 30. Biochemistry. 2022. PMID: 35771007 Free PMC article.

7

A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins.

Aguayo-Ortiz R, Creech J, Jiménez-Vázquez EN, Guerrero-Serna G, Wang N, da Rocha AM, Herron TJ, Espinoza-Fonseca LM. Aguayo-Ortiz R, et al. Sci Rep. 2021 Aug 16;11(1):16580. doi: 10.1038/s41598-021-96217-7. Sci Rep. 2021. PMID: 34400719 Free PMC article.

8

A hallmark of phospholamban functional divergence is located in the N-terminal phosphorylation domain.

Fernández-de Gortari E, Aguayo-Ortiz R, Autry JM, Michel Espinoza-Fonseca L. Fernández-de Gortari E, et al. Comput Struct Biotechnol J. 2020 Feb 28;18:705-713. doi: 10.1016/j.csbj.2020.02.016. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32257054 Free PMC article.

9

Homologous cardiac calcium pump regulators phospholamban and sarcolipin adopt distinct oligomeric states in the membrane.

Liu AY, Aguayo-Ortiz R, Guerrero-Serna G, Wang N, Blin MG, Goldstein DR, Michel Espinoza-Fonseca L. Liu AY, et al. Comput Struct Biotechnol J. 2021 Dec 28;20:380-384. doi: 10.1016/j.csbj.2021.12.031. eCollection 2022. Comput Struct Biotechnol J. 2021. PMID: 35035790 Free PMC article.

10

Effects of Mutating Trp42 Residue on γD-Crystallin Stability.

Aguayo-Ortiz R, Dominguez L. Aguayo-Ortiz R, et al. J Chem Inf Model. 2020 Feb 24;60(2):777-785. doi: 10.1021/acs.jcim.9b00747. Epub 2019 Dec 4. J Chem Inf Model. 2020. PMID: 31747273

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