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The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Cadilla R, Deaton DN, Do Y, Elkins PA, Ennulat D, Guss JH, Holt J, Jeune MR, King AG, Klapwijk JC, Kramer HF, Kramer NJ, Laffan SB, Masuria PI, McDougal AV, Mortenson PN, Musetti C, Peckham GE, Pietrak BL, Poole C, Price DJ, Rendina AR, Sati G, Saxty G, Shearer BG, Shewchuk LM, Sneddon HF, Stewart EL, Stuart JD, Thomas DN, Thomson SA, Ward P, Wilson JW, Xu T, Youngman MA. Cadilla R, et al. Among authors: sneddon hf. Bioorg Med Chem. 2020 Dec 1;28(23):115791. doi: 10.1016/j.bmc.2020.115791. Epub 2020 Oct 3. Bioorg Med Chem. 2020. PMID: 33059303
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Deaton DN, Do Y, Holt J, Jeune MR, Kramer HF, Larkin AL, Orband-Miller LA, Peckham GE, Poole C, Price DJ, Schaller LT, Shen Y, Shewchuk LM, Stewart EL, Stuart JD, Thomson SA, Ward P, Wilson JW, Xu T, Guss JH, Musetti C, Rendina AR, Affleck K, Anders D, Hancock AP, Hobbs H, Hodgson ST, Hutchinson J, Leveridge MV, Nicholls H, Smith IED, Somers DO, Sneddon HF, Uddin S, Cleasby A, Mortenson PN, Richardson C, Saxty G. Deaton DN, et al. Among authors: sneddon hf. Bioorg Med Chem. 2019 Apr 15;27(8):1456-1478. doi: 10.1016/j.bmc.2019.02.017. Epub 2019 Feb 11. Bioorg Med Chem. 2019. PMID: 30858025
Generation and Trapping of Ketenes in Flow.
Henry C, Bolien D, Ibanescu B, Bloodworth S, Harrowven DC, Zhang X, Craven A, Sneddon HF, Whitby RJ. Henry C, et al. Among authors: sneddon hf. European J Org Chem. 2015 Mar;2015(7):1491-1499. doi: 10.1002/ejoc.201403603. Epub 2015 Jan 20. European J Org Chem. 2015. PMID: 26097406 Free PMC article.
Synthesis of 18O-labelled alcohols from unlabelled alcohols.
Beddoe RH, Edwards DC, Goodman L, Sneddon HF, Denton RM. Beddoe RH, et al. Among authors: sneddon hf. Chem Commun (Camb). 2020 Jun 16;56(48):6480-6483. doi: 10.1039/d0cc02855j. Chem Commun (Camb). 2020. PMID: 32453324
27 results