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SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.
Fedele C, Li S, Teng KW, Foster CJR, Peng D, Ran H, Mita P, Geer MJ, Hattori T, Koide A, Wang Y, Tang KH, Leinwand J, Wang W, Diskin B, Deng J, Chen T, Dolgalev I, Ozerdem U, Miller G, Koide S, Wong KK, Neel BG. Fedele C, et al. Among authors: miller g. J Exp Med. 2021 Jan 4;218(1):e20201414. doi: 10.1084/jem.20201414. J Exp Med. 2021. PMID: 33045063 Free PMC article.
TLR9 ligation in pancreatic stellate cells promotes tumorigenesis.
Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, Seifert L, Daley D, Greco SH, Deutsch M, Jonnadula S, Torres-Hernandez A, Tippens D, Pushalkar S, Eisenthal A, Saxena D, Ahn J, Hajdu C, Engle DD, Tuveson D, Miller G. Zambirinis CP, et al. Among authors: miller g. J Exp Med. 2015 Nov 16;212(12):2077-94. doi: 10.1084/jem.20142162. Epub 2015 Oct 19. J Exp Med. 2015. PMID: 26481685 Free PMC article.
Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.
Daley D, Mani VR, Mohan N, Akkad N, Ochi A, Heindel DW, Lee KB, Zambirinis CP, Pandian GSB, Savadkar S, Torres-Hernandez A, Nayak S, Wang D, Hundeyin M, Diskin B, Aykut B, Werba G, Barilla RM, Rodriguez R, Chang S, Gardner L, Mahal LK, Ueberheide B, Miller G. Daley D, et al. Among authors: miller g. Nat Med. 2017 May;23(5):556-567. doi: 10.1038/nm.4314. Epub 2017 Apr 10. Nat Med. 2017. PMID: 28394331 Free PMC article.
NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.
Daley D, Mani VR, Mohan N, Akkad N, Pandian GSDB, Savadkar S, Lee KB, Torres-Hernandez A, Aykut B, Diskin B, Wang W, Farooq MS, Mahmud AI, Werba G, Morales EJ, Lall S, Wadowski BJ, Rubin AG, Berman ME, Narayanan R, Hundeyin M, Miller G. Daley D, et al. Among authors: miller g. J Exp Med. 2017 Jun 5;214(6):1711-1724. doi: 10.1084/jem.20161707. Epub 2017 Apr 25. J Exp Med. 2017. PMID: 28442553 Free PMC article.
The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.
Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, Werba G, Zhang K, Guo Y, Li Q, Akkad N, Lall S, Wadowski B, Gutierrez J, Kochen Rossi JA, Herzog JW, Diskin B, Torres-Hernandez A, Leinwand J, Wang W, Taunk PS, Savadkar S, Janal M, Saxena A, Li X, Cohen D, Sartor RB, Saxena D, Miller G. Pushalkar S, et al. Among authors: miller g. Cancer Discov. 2018 Apr;8(4):403-416. doi: 10.1158/2159-8290.CD-17-1134. Epub 2018 Mar 22. Cancer Discov. 2018. PMID: 29567829 Free PMC article.
Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?
Grunhut J, Wang W, Aykut B, Gakhal I, Torres-Hernandez A, Miller G. Grunhut J, et al. Among authors: miller g. Eur Med J Hepatol. 2018;6(1):100-109. Epub 2018 May 31. Eur Med J Hepatol. 2018. PMID: 29930864 Free PMC article.
6,152 results