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Page 1
Landscape of coordinated immune responses to H1N1 challenge in humans.
Rahil Z, Leylek R, Schürch CM, Chen H, Bjornson-Hooper Z, Christensen SR, Gherardini PF, Bhate SS, Spitzer MH, Fragiadakis GK, Mukherjee N, Kim N, Jiang S, Yo J, Gaudilliere B, Affrime M, Bock B, Hensley SE, Idoyaga J, Aghaeepour N, Kim K, Nolan GP, McIlwain DR. Rahil Z, et al. Among authors: mcilwain dr. J Clin Invest. 2020 Nov 2;130(11):5800-5816. doi: 10.1172/JCI137265. J Clin Invest. 2020. PMID: 33044226 Free PMC article. Clinical Trial.
T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.
McIlwain DR, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP, Lang KS, Lang PA. McIlwain DR, et al. Eur J Immunol. 2015 Feb;45(2):418-27. doi: 10.1002/eji.201445060. Epub 2014 Dec 15. Eur J Immunol. 2015. PMID: 25393615 Free PMC article.
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA. Maney SK, et al. Among authors: mcilwain dr. Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356. Sci Signal. 2015. PMID: 26535007 Free PMC article.
An immune clock of human pregnancy.
Aghaeepour N, Ganio EA, Mcilwain D, Tsai AS, Tingle M, Van Gassen S, Gaudilliere DK, Baca Q, McNeil L, Okada R, Ghaemi MS, Furman D, Wong RJ, Winn VD, Druzin ML, El-Sayed YY, Quaintance C, Gibbs R, Darmstadt GL, Shaw GM, Stevenson DK, Tibshirani R, Nolan GP, Lewis DB, Angst MS, Gaudilliere B. Aghaeepour N, et al. Sci Immunol. 2017 Sep 1;2(15):eaan2946. doi: 10.1126/sciimmunol.aan2946. Sci Immunol. 2017. PMID: 28864494 Free PMC article.
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy.
Ghaemi MS, DiGiulio DB, Contrepois K, Callahan B, Ngo TTM, Lee-McMullen B, Lehallier B, Robaczewska A, Mcilwain D, Rosenberg-Hasson Y, Wong RJ, Quaintance C, Culos A, Stanley N, Tanada A, Tsai A, Gaudilliere D, Ganio E, Han X, Ando K, McNeil L, Tingle M, Wise P, Maric I, Sirota M, Wyss-Coray T, Winn VD, Druzin ML, Gibbs R, Darmstadt GL, Lewis DB, Partovi Nia V, Agard B, Tibshirani R, Nolan G, Snyder MP, Relman DA, Quake SR, Shaw GM, Stevenson DK, Angst MS, Gaudilliere B, Aghaeepour N. Ghaemi MS, et al. Bioinformatics. 2019 Jan 1;35(1):95-103. doi: 10.1093/bioinformatics/bty537. Bioinformatics. 2019. PMID: 30561547 Free PMC article.
Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.
Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. Lee IT, et al. Among authors: mcilwain dr. medRxiv [Preprint]. 2020 May 12:2020.05.08.20092866. doi: 10.1101/2020.05.08.20092866. medRxiv. 2020. Update in: Nat Commun. 2020 Oct 28;11(1):5453. doi: 10.1038/s41467-020-19145-6 PMID: 32511516 Free PMC article. Updated. Preprint.
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Chen H, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tzankov A, Matter MS, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. Lee IT, et al. Among authors: mcilwain dr. Nat Commun. 2020 Oct 28;11(1):5453. doi: 10.1038/s41467-020-19145-6. Nat Commun. 2020. PMID: 33116139 Free PMC article.
52 results