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Page 1
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL. Rynearson KD, et al. Among authors: wagner sl. Bioorg Med Chem. 2020 Nov 15;28(22):115734. doi: 10.1016/j.bmc.2020.115734. Epub 2020 Sep 1. Bioorg Med Chem. 2020. PMID: 33007551 Free PMC article.
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.
Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D. Saunders AJ, et al. Among authors: wagner sl. Hum Mol Genet. 2003 Nov 1;12(21):2765-76. doi: 10.1093/hmg/ddg310. Epub 2003 Sep 9. Hum Mol Genet. 2003. PMID: 12966032
Family-based association between Alzheimer's disease and variants in UBQLN1.
Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. Bertram L, et al. Among authors: wagner sl. N Engl J Med. 2005 Mar 3;352(9):884-94. doi: 10.1056/NEJMoa042765. N Engl J Med. 2005. PMID: 15745979 Free article.
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Hiltunen M, et al. Among authors: wagner sl. J Biol Chem. 2006 Oct 27;281(43):32240-53. doi: 10.1074/jbc.M603106200. Epub 2006 Aug 31. J Biol Chem. 2006. PMID: 16945923 Free article.
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Kounnas MZ, et al. Among authors: wagner sl. Neuron. 2010 Sep 9;67(5):769-80. doi: 10.1016/j.neuron.2010.08.018. Neuron. 2010. PMID: 20826309 Free PMC article.
And four equals one: presenilin takes the gamma-secretase role by itself.
Lessard CB, Wagner SL, Koo EH. Lessard CB, et al. Among authors: wagner sl. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21236-7. doi: 10.1073/pnas.1016284108. Epub 2010 Dec 6. Proc Natl Acad Sci U S A. 2010. PMID: 21135249 Free PMC article. No abstract available.
Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G. Vetrivel KS, et al. Among authors: wagner sl. J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3. J Biol Chem. 2011. PMID: 21642424 Free PMC article.
129 results