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PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling.
Baffi TR, Cohen-Katsenelson K, Newton AC. Baffi TR, et al. Among authors: newton ac. Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:723-743. doi: 10.1146/annurev-pharmtox-031820-122108. Epub 2020 Sep 30. Annu Rev Pharmacol Toxicol. 2021. PMID: 32997603 Free PMC article. Review.
PHLiPPing the switch on Akt and protein kinase C signaling.
Brognard J, Newton AC. Brognard J, et al. Among authors: newton ac. Trends Endocrinol Metab. 2008 Aug;19(6):223-30. doi: 10.1016/j.tem.2008.04.001. Epub 2008 May 27. Trends Endocrinol Metab. 2008. PMID: 18511290 Free PMC article. Review.
PHLPP-1 negatively regulates Akt activity and survival in the heart.
Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. Miyamoto S, et al. Among authors: newton ac. Circ Res. 2010 Aug 20;107(4):476-84. doi: 10.1161/CIRCRESAHA.109.215020. Epub 2010 Jun 24. Circ Res. 2010. PMID: 20576936 Free PMC article.
Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. Warfel NA, et al. Among authors: newton ac. J Biol Chem. 2011 Jun 3;286(22):19777-88. doi: 10.1074/jbc.M111.237081. Epub 2011 Mar 28. J Biol Chem. 2011. PMID: 21454620 Free PMC article.
282 results