Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol.
Tang VT, McCormick J, Xu B, Wang Y, Fang H, Wang X, Siemieniak D, Khoriaty R, Emmer BT, Chen XW, Ginsburg D.
Tang VT, et al. Among authors: emmer bt.
Elife. 2022 Oct 4;11:e82269. doi: 10.7554/eLife.82269.
Elife. 2022.
PMID: 36193893
Free PMC article.
We previously identified SURF4 as a cargo receptor that facilitates PCSK9 secretion in HEK293T cells (Emmer et al., 2018). Here, we generated hepatic SURF4-deficient mice (Surf4(fl/fl) Alb-Cre(+)) to investigate the physiologic role of SURF4 in vivo. ...Detailed characteri …
We previously identified SURF4 as a cargo receptor that facilitates PCSK9 secretion in HEK293T cells (Emmer et al., 2018). Here, we g …