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Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.
Tamada K, Nakajima S, Ogawa N, Inada M, Shibasaki H, Sato A, Takasawa R, Yoshimori A, Suzuki Y, Watanabe N, Oyama T, Abe H, Inoue S, Abe T, Yokomizo T, Tanuma S. Tamada K, et al. Biochem Biophys Res Commun. 2019 Apr 9;511(3):665-670. doi: 10.1016/j.bbrc.2019.01.136. Epub 2019 Feb 27. Biochem Biophys Res Commun. 2019. PMID: 30826057
Trimebutine attenuates high mobility group box 1-receptor for advanced glycation end-products inflammatory signaling pathways.
Nakajima S, Ogawa N, Yokoue N, Tachibana H, Tamada K, Okazawa M, Sato A, Oyama T, Abe H, Kamiya T, Yoshimori A, Yoshizawa K, Inoue S, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Nakajima S, et al. Among authors: tanuma si. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1155-1161. doi: 10.1016/j.bbrc.2020.09.126. Epub 2020 Oct 8. Biochem Biophys Res Commun. 2020. PMID: 33041002
A 3-styrylchromone converted from trimebutine 3D pharmacophore possesses dual suppressive effects on RAGE and TLR4 signaling pathways.
Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Tsukimoto M, Yoshizawa K, Takao K, Sugita Y, Kamiya T, Uchiumi F, Sakagami H, Abe T, Tanuma SI. Okazawa M, et al. Among authors: tanuma si. Biochem Biophys Res Commun. 2021 Aug 20;566:1-8. doi: 10.1016/j.bbrc.2021.05.096. Epub 2021 Jun 7. Biochem Biophys Res Commun. 2021. PMID: 34111666
Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages.
Ogawa N, Nakajima S, Tamada K, Yokoue N, Tachibana H, Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Sato A, Kamiya T, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Ogawa N, et al. Among authors: tanuma si. Arch Biochem Biophys. 2021 Oct 30;711:109029. doi: 10.1016/j.abb.2021.109029. Epub 2021 Sep 10. Arch Biochem Biophys. 2021. PMID: 34517011
In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system.
El-Far AHAM, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma SI, Yamamoto Y. El-Far AHAM, et al. Among authors: tanuma si. Oncol Lett. 2018 Apr;15(4):4627-4634. doi: 10.3892/ol.2018.7902. Epub 2018 Jan 29. Oncol Lett. 2018. PMID: 29541234 Free PMC article.
237 results