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Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity.
Costa MS, Gonçalves YG, Borges BC, Silva MJB, Amstalden MK, Costa TR, Antunes LMG, Rodrigues RS, Rodrigues VM, de Faria Franca E, Zoia MAP, de Araújo TG, Goulart LR, Von Poelhsitz G, Yoneyama KAG. Costa MS, et al. Among authors: costa tr. Sci Rep. 2020 Sep 21;10(1):15410. doi: 10.1038/s41598-020-72420-w. Sci Rep. 2020. PMID: 32958783 Free PMC article.
A comparative study on the leishmanicidal activity of the L-amino acid oxidases BjussuLAAO-II and BmooLAAO-II isolated from Brazilian Bothrops snake venoms.
Barbosa LG, Costa TR, Borges IP, Costa MS, Carneiro AC, Borges BC, Silva MJB, Amorim FG, Quinton L, Yoneyama KAG, de Melo Rodrigues V, Sampaio SV, Rodrigues RS. Barbosa LG, et al. Among authors: costa ms, costa tr. Int J Biol Macromol. 2021 Jan 15;167:267-278. doi: 10.1016/j.ijbiomac.2020.11.146. Epub 2020 Nov 24. Int J Biol Macromol. 2021. PMID: 33242552
Biochemical characterization and assessment of leishmanicidal effects of a new L-amino acid oxidase from Crotalus durissus collilineatus snake venom (CollinLA AO-I).
de Freitas V, Costa TR, Nogueira AR, Polloni L, Alves de Melo Fernandes T, Correia LIV, Borges BC, Teixeira SC, Silva MJB, Amorim FG, Quinton L, Saraiva AL, Espindola FS, Iwai LK, Rodrigues RS, Yoneyama KAG, de Melo Rodrigues Ávila V. de Freitas V, et al. Among authors: costa tr. Toxicon. 2023 Jul;230:107156. doi: 10.1016/j.toxicon.2023.107156. Epub 2023 May 9. Toxicon. 2023. PMID: 37169266
Oxidative stress induced by Pollonein-LAAO, a new L-amino acid oxidase from Bothrops moojeni venom, prompts prostate tumor spheroid cell death and impairs the cellular invasion process in vitro.
Polloni L, Costa TR, Morais LP, Borges BC, Teixeira SC, de Melo Fernandes TA, Correia LIV, Bastos LM, Amorim FG, Quinton L, Soares AM, Silva MJB, Ferro EAV, Lopes DS, de Melo Rodrigues Ávila V. Polloni L, et al. Among authors: costa tr. Cell Signal. 2023 Sep;109:110785. doi: 10.1016/j.cellsig.2023.110785. Epub 2023 Jun 25. Cell Signal. 2023. PMID: 37364850
Antileishmanial effects of γCdcPLI, a phospholipase A2 inhibitor from Crotalus durissus collilineatus snake serum, on Leishmania (Leishmania) amazonensis.
Gonçalves MN, Lopes DS, Teixeira SC, Teixeira TL, de Freitas V, Costa TR, Gimenes SNC, de Camargo IM, de Souza G, da Silva MS, Azevedo FVPV, Grego KF, Santos LC, Oliveira VQ, da Silva CV, Rodrigues RS, Yoneyama KAG, Clissa PB, Rodrigues VM. Gonçalves MN, et al. Among authors: costa tr. Mem Inst Oswaldo Cruz. 2023 Nov 27;118:e220225. doi: 10.1590/0074-02760220225. eCollection 2023. Mem Inst Oswaldo Cruz. 2023. PMID: 38018570 Free PMC article.
Pollonein-LAAO unveiling anti-angiogenic effects through oxidative stress: Insights from mimetic tumor angiogenesis environment in a 3D co-culture model.
Polloni L, Costa TR, Morais LP, Borges BC, Teixeira SC, de Melo Fernandes TA, Correia LIV, Bastos LM, Soares AM, Silva MJB, Amália Vieira Ferro E, Lopes DS, Ávila VMR. Polloni L, et al. Among authors: costa tr. Chem Biol Interact. 2024 Dec 21;406:111361. doi: 10.1016/j.cbi.2024.111361. Online ahead of print. Chem Biol Interact. 2024. PMID: 39716533 No abstract available.
Towards toxin PEGylation: The example of rCollinein-1, a snake venom thrombin-like enzyme, as a PEGylated biopharmaceutical prototype.
Pinheiro-Junior EL, Boldrini-França J, Takeda AAS, Costa TR, Peigneur S, Cardoso IA, Oliveira IS, Sampaio SV, de Mattos Fontes MR, Tytgat J, Arantes EC. Pinheiro-Junior EL, et al. Among authors: costa tr. Int J Biol Macromol. 2021 Nov 1;190:564-573. doi: 10.1016/j.ijbiomac.2021.09.004. Epub 2021 Sep 7. Int J Biol Macromol. 2021. PMID: 34506860
116 results