Murphy MJ - Search Results

1

Preclinical to clinical translation of cenerimod, a novel S1P₁ receptor modulator, in systemic lupus erythematosus.

Strasser DS, Froidevaux S, Sippel V, Gerossier E, Grieder U, Pierlot GM, Kieninger-Graefitsch A, Vezzali E, Stalder AK, Renault B, Ryge J, Hart A, Mentzel U, Groenen PMA, Keller MP, Trendelenburg M, Martinic MM, Murphy MJ. Strasser DS, et al. Among authors: murphy mj. RMD Open. 2020 Sep;6(2):e001261. doi: 10.1136/rmdopen-2020-001261. RMD Open. 2020. PMID: 32917831 Free PMC article.

2

Cenerimod, a selective S1P₁ receptor modulator, improves organ-specific disease outcomes in animal models of Sjögren's syndrome.

Gerossier E, Nayar S, Froidevaux S, Smith CG, Runser C, Iannizzotto V, Vezzali E, Pierlot G, Mentzel U, Murphy MJ, Martinic MM, Barone F. Gerossier E, et al. Among authors: murphy mj. Arthritis Res Ther. 2021 Nov 29;23(1):289. doi: 10.1186/s13075-021-02673-x. Arthritis Res Ther. 2021. PMID: 34839819 Free PMC article.

3

In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P₁) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P₁ Receptor Modulator.

Schlicher L, Kulig P, von Münchow A, Murphy MJ, Keller MP. Schlicher L, et al. Among authors: murphy mj. Int J Mol Sci. 2022 Jan 21;23(3):1191. doi: 10.3390/ijms23031191. Int J Mol Sci. 2022. PMID: 35163112 Free PMC article.

4

Pharmacodynamics of the S1P₁ receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

Suffiotti M, Brazauskas P, Keller MP, Berkani O, Seifer G, Cornelisse P, Murphy MJ, Strasser DS. Suffiotti M, et al. Among authors: murphy mj. Ann Rheum Dis. 2024 Nov 24:ard-2024-226547. doi: 10.1136/ard-2024-226547. Online ahead of print. Ann Rheum Dis. 2024. PMID: 39581631 Free article.

5

Cenerimod, a sphingosine-1-phosphate receptor modulator, versus placebo in patients with moderate-to-severe systemic lupus erythematosus (CARE): an international, double-blind, randomised, placebo-controlled, phase 2 trial.

Askanase AD, D'Cruz D, Kalunian K, Merrill JT, Navarra SV, Cahuzac C, Cornelisse P, Murphy MJ, Strasser DS, Trokan L, Berkani O. Askanase AD, et al. Among authors: murphy mj. Lancet Rheumatol. 2025 Jan;7(1):e21-e32. doi: 10.1016/S2665-9913(24)00246-7. Epub 2024 Nov 22. Lancet Rheumatol. 2025. PMID: 39586304 Clinical Trial.

6

The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration.

Baumann M, Lack B, Guillaumat I, Murphy MJ, Riederer MA. Baumann M, et al. Among authors: murphy mj. Platelets. 2022 Jan 2;33(1):147-156. doi: 10.1080/09537104.2020.1869711. Epub 2021 Jan 11. Platelets. 2022. PMID: 33427002 Free article.

7

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor.

Seeland S, Kettiger H, Murphy M, Treiber A, Giller J, Kiss A, Sube R, Krähenbühl S, Hafner M, Huwyler J. Seeland S, et al. Pharmacol Res Perspect. 2015 Mar;3(2):e00123. doi: 10.1002/prp2.123. Epub 2015 Mar 12. Pharmacol Res Perspect. 2015. PMID: 26038699 Free PMC article.

8

Lack of regulation of the modification-dependent restriction enzyme McrBC in Escherichia coli.

Murphy M, Schmid Nuoffer S, Bickle TA. Murphy M, et al. J Bacteriol. 2002 Mar;184(6):1794-5. doi: 10.1128/JB.184.6.1794-1795.2002. J Bacteriol. 2002. PMID: 11872734 Free PMC article.

9

The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome.

Smith-Jackson K, Walsh P, Zelek WM, Hoyler T, Martinic MM, Thompson G, Gibson B, Connelly C, Pappworth I, Murphy MJ, Kavanagh D, Marchbank KJ. Smith-Jackson K, et al. Among authors: murphy mj. Kidney Int. 2025 Jan 21:S0085-2538(25)00060-2. doi: 10.1016/j.kint.2024.12.016. Online ahead of print. Kidney Int. 2025. PMID: 39848404

10

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis.

Scahill RI, Farag M, Murphy MJ, Hobbs NZ, Leocadi M, Langley C, Knights H, Ciosi M, Fayer K, Nakajima M, Thackeray O, Gobom J, Rönnholm J, Weiner S, Hassan YR, Ponraj NKP, Estevez-Fraga C, Parker CS, Malone IB, Hyare H, Long JD, Heslegrave A, Sampaio C, Zhang H, Robbins TW, Zetterberg H, Wild EJ, Rees G, Rowe JB, Sahakian BJ, Monckton DG, Langbehn DR, Tabrizi SJ. Scahill RI, et al. Among authors: murphy mj. Nat Med. 2025 Jan 17. doi: 10.1038/s41591-024-03424-6. Online ahead of print. Nat Med. 2025. PMID: 39825149

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