Jenkins L - Search Results

1

Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.

Labéguère F, Dupont S, Alvey L, Soulas F, Newsome G, Tirera A, Quenehen V, Mai TTT, Deprez P, Blanqué R, Oste L, Le Tallec S, De Vos S, Hagers A, Vandevelde A, Nelles L, Vandervoort N, Conrath K, Christophe T, van der Aar E, Wakselman E, Merciris D, Cottereaux C, da Costa C, Saniere L, Clement-Lacroix P, Jenkins L, Milligan G, Fletcher S, Brys R, Gosmini R. Labéguère F, et al. Among authors: jenkins l. J Med Chem. 2020 Nov 25;63(22):13526-13545. doi: 10.1021/acs.jmedchem.0c00272. Epub 2020 Sep 23. J Med Chem. 2020. PMID: 32902984 Free article. Clinical Trial.

2

Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.

Canals M, Jenkins L, Kellett E, Milligan G. Canals M, et al. Among authors: jenkins l. J Biol Chem. 2006 Jun 16;281(24):16757-67. doi: 10.1074/jbc.M601121200. Epub 2006 Apr 11. J Biol Chem. 2006. PMID: 16611642 Free article.

3

Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.

Francke F, Ward RJ, Jenkins L, Kellett E, Richter D, Milligan G, Bächner D. Francke F, et al. Among authors: jenkins l. J Biol Chem. 2006 Oct 27;281(43):32496-507. doi: 10.1074/jbc.M602889200. Epub 2006 Aug 31. J Biol Chem. 2006. PMID: 16945926 Free article.

4

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.

Stoddart LA, Smith NJ, Jenkins L, Brown AJ, Milligan G. Stoddart LA, et al. Among authors: jenkins l. J Biol Chem. 2008 Nov 21;283(47):32913-24. doi: 10.1074/jbc.M805601200. Epub 2008 Sep 18. J Biol Chem. 2008. PMID: 18801738 Free article.

5

Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin.

Ward RJ, Jenkins L, Milligan G. Ward RJ, et al. Among authors: jenkins l. J Neurochem. 2009 Apr;109(1):182-92. doi: 10.1111/j.1471-4159.2009.05918.x. Epub 2009 Jan 23. J Neurochem. 2009. PMID: 19166508 Free article.

6

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.

Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G. Smith NJ, et al. Among authors: jenkins l. J Biol Chem. 2009 Jun 26;284(26):17527-39. doi: 10.1074/jbc.M109.012849. Epub 2009 Apr 27. J Biol Chem. 2009. PMID: 19398560 Free PMC article.

7

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Jenkins L, Brea J, Smith NJ, Hudson BD, Reilly G, Bryant NJ, Castro M, Loza MI, Milligan G. Jenkins L, et al. Biochem J. 2010 Dec 15;432(3):451-9. doi: 10.1042/BJ20101287. Biochem J. 2010. PMID: 20919992

8

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

Jenkins L, Alvarez-Curto E, Campbell K, de Munnik S, Canals M, Schlyer S, Milligan G. Jenkins L, et al. Br J Pharmacol. 2011 Feb;162(3):733-48. doi: 10.1111/j.1476-5381.2010.01082.x. Br J Pharmacol. 2011. PMID: 20958291 Free PMC article.

9

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.

Jenkins L, Harries N, Lappin JE, MacKenzie AE, Neetoo-Isseljee Z, Southern C, McIver EG, Nicklin SA, Taylor DL, Milligan G. Jenkins L, et al. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95. doi: 10.1124/jpet.112.198945. Epub 2012 Sep 11. J Pharmacol Exp Ther. 2012. PMID: 22967846 Free PMC article.

10

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.

Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T. Christiansen E, et al. Among authors: jenkins l. ACS Med Chem Lett. 2013 May 9;4(5):441-445. doi: 10.1021/ml4000673. Epub 2013 Apr 8. ACS Med Chem Lett. 2013. PMID: 23687558 Free PMC article.

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