Hunt HJ - Search Results

1

An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes.

Custodio JM, Donaldson KM, Hunt HJ. Custodio JM, et al. Among authors: hunt hj. J Clin Pharmacol. 2021 Feb;61(2):244-253. doi: 10.1002/jcph.1731. Epub 2020 Aug 31. J Clin Pharmacol. 2021. PMID: 32869328 Free PMC article. Clinical Trial.

2

Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).

Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR. Webster SP, et al. Among authors: hunt hj. Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25. Br J Pharmacol. 2017. PMID: 28012176 Free PMC article. Clinical Trial.

3

Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double-Blind, Randomized, Placebo-Controlled Phase 1 Clinical Study.

Hunt H, Donaldson K, Strem M, Zann V, Leung P, Sweet S, Connor A, Combs D, Belanoff J. Hunt H, et al. Clin Pharmacol Drug Dev. 2018 May;7(4):408-421. doi: 10.1002/cpdd.389. Epub 2017 Oct 2. Clin Pharmacol Drug Dev. 2018. PMID: 28967708 Free PMC article. Clinical Trial.

4

Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects: A Proof-of-Concept Study.

Hunt HJ, Donaldson K, Strem M, Tudor IC, Sweet-Smith S, Sidhu S. Hunt HJ, et al. J Clin Psychopharmacol. 2021 Nov-Dec 01;41(6):632-637. doi: 10.1097/JCP.0000000000001470. J Clin Psychopharmacol. 2021. PMID: 34369902 Free PMC article. Clinical Trial.

5

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.

van den Heuvel JK, Boon MR, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, van Dijk KW, Pereira AM, Hunt H, Belanoff JK, Rensen PC, Meijer OC. van den Heuvel JK, et al. Br J Pharmacol. 2016 Jun;173(11):1793-804. doi: 10.1111/bph.13477. Epub 2016 Apr 24. Br J Pharmacol. 2016. PMID: 26990179 Free PMC article.

6

FKBP5 mRNA Expression Is a Biomarker for GR Antagonism.

Bali U, Phillips T, Hunt H, Unitt J. Bali U, et al. J Clin Endocrinol Metab. 2016 Nov;101(11):4305-4312. doi: 10.1210/jc.2016-1624. Epub 2016 Jul 26. J Clin Endocrinol Metab. 2016. PMID: 27459525 Clinical Trial.

7

Mifepristone Decreases Chronic Voluntary Ethanol Consumption in Rhesus Macaques.

Jimenez VA, Walter NAR, Shnitko TA, Newman N, Diem K, Vanderhooft L, Hunt H, Grant KA. Jimenez VA, et al. J Pharmacol Exp Ther. 2020 Nov;375(2):258-267. doi: 10.1124/jpet.120.000169. Epub 2020 Sep 1. J Pharmacol Exp Ther. 2020. PMID: 32873623 Free PMC article.

8

The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol.

Greenstein AE, Hunt HJ. Greenstein AE, et al. Among authors: hunt hj. Int Immunopharmacol. 2023 Jul;120:110312. doi: 10.1016/j.intimp.2023.110312. Epub 2023 May 23. Int Immunopharmacol. 2023. PMID: 37230031

9

Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice.

Kroon J, Gentenaar M, Moll TJA, Hunt H, Meijer OC. Kroon J, et al. Eur J Pharmacol. 2023 Oct 15;957:176012. doi: 10.1016/j.ejphar.2023.176012. Epub 2023 Aug 25. Eur J Pharmacol. 2023. PMID: 37634839 Free article.

10

Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice.

Kroon J, Koorneef LL, van den Heuvel JK, Verzijl CRC, van de Velde NM, Mol IM, Sips HCM, Hunt H, Rensen PCN, Meijer OC. Kroon J, et al. Endocrinology. 2018 Jan 1;159(1):535-546. doi: 10.1210/en.2017-00512. Endocrinology. 2018. PMID: 28938459

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