Nicolaou KC - Search Results

1

Streamlined Symmetrical Total Synthesis of Disorazole B₁ and Design, Synthesis, and Biological Investigation of Disorazole Analogues.

Nicolaou KC, Krieger J, Murhade GM, Subramanian P, Dherange BD, Vourloumis D, Munneke S, Lin B, Gu C, Sarvaiaya H, Sandoval J, Zhang Z, Aujay M, Purcell JW, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2020 Sep 9;142(36):15476-15487. doi: 10.1021/jacs.0c07094. Epub 2020 Aug 27. J Am Chem Soc. 2020. PMID: 32852944

2

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins.

Nicolaou KC, Yin J, Mandal D, Erande RD, Klahn P, Jin M, Aujay M, Sandoval J, Gavrilyuk J, Vourloumis D. Nicolaou KC, et al. J Am Chem Soc. 2016 Feb 10;138(5):1698-708. doi: 10.1021/jacs.5b12557. Epub 2016 Feb 1. J Am Chem Soc. 2016. PMID: 26829208

3

Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds.

Nicolaou KC, Pulukuri KK, Rigol S, Heretsch P, Yu R, Grove CI, Hale CR, ElMarrouni A, Fetz V, Brönstrup M, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2016 May 25;138(20):6550-60. doi: 10.1021/jacs.6b02075. Epub 2016 May 12. J Am Chem Soc. 2016. PMID: 27171618

4

12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents.

Nicolaou KC, Rhoades D, Wang Y, Bai R, Hamel E, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2017 May 31;139(21):7318-7334. doi: 10.1021/jacs.7b02655. Epub 2017 May 17. J Am Chem Soc. 2017. PMID: 28513142

5

Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.

Nicolaou KC, Chen P, Zhu S, Cai Q, Erande RD, Li R, Sun H, Pulukuri KK, Rigol S, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2017 Nov 1;139(43):15467-15478. doi: 10.1021/jacs.7b08820. Epub 2017 Oct 20. J Am Chem Soc. 2017. PMID: 29052423

6

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.

Nicolaou KC, Erande RD, Yin J, Vourloumis D, Aujay M, Sandoval J, Munneke S, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2018 Mar 14;140(10):3690-3711. doi: 10.1021/jacs.7b12692. Epub 2018 Jan 30. J Am Chem Soc. 2018. PMID: 29381062

7

Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.

Nicolaou KC, Li R, Lu Z, Pitsinos EN, Alemany LB, Aujay M, Lee C, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2018 Sep 26;140(38):12120-12136. doi: 10.1021/jacs.8b06955. Epub 2018 Sep 14. J Am Chem Soc. 2018. PMID: 30216054

8

Syntheses of Cyclopropyl Analogues of Disorazoles A₁ and B₁ and Their Thiazole Counterparts.

Nicolaou KC, Buchman M, Bellavance G, Krieger J, Subramanian P, Pulukuri KK. Nicolaou KC, et al. J Org Chem. 2018 Oct 19;83(20):12374-12389. doi: 10.1021/acs.joc.8b02137. Epub 2018 Oct 2. J Org Chem. 2018. PMID: 30277774

9

Short Total Synthesis of Δ¹²-Prostaglandin J₂ and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ¹²-Prostaglandin J₂ Analogues.

Nicolaou KC, Pulukuri KK, Rigol S, Peitsinis Z, Yu R, Kishigami S, Cen N, Aujay M, Sandoval J, Zepeda N, Gavrilyuk J. Nicolaou KC, et al. J Org Chem. 2019 Jan 4;84(1):365-378. doi: 10.1021/acs.joc.8b03057. Epub 2018 Dec 20. J Org Chem. 2019. PMID: 30557504

10

Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics.

Nicolaou KC, Das D, Lu Y, Rout S, Pitsinos EN, Lyssikatos J, Schammel A, Sandoval J, Hammond M, Aujay M, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2020 Feb 5;142(5):2549-2561. doi: 10.1021/jacs.9b12522. Epub 2020 Jan 24. J Am Chem Soc. 2020. PMID: 31976660

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