Yan Z - Search Results

1

Inter-individual and inter-regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors.

Li AP, Ho MD, Alam N, Mitchell W, Wong S, Yan Z, Kenny JR, E C A Hop C. Li AP, et al. Among authors: yan z. Pharmacol Res Perspect. 2020 Oct;8(5):e00645. doi: 10.1002/prp2.645. Pharmacol Res Perspect. 2020. PMID: 32851819 Free PMC article.

2

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions.

Wong S, Doshi U, Vuong P, Liu N, Tay S, Le H, Kosaka M, Kenny JR, Li AP, Yan Z. Wong S, et al. Among authors: yan z. Drug Metab Lett. 2018;12(1):3-13. doi: 10.2174/1872312812666171213114422. Drug Metab Lett. 2018. PMID: 29237391

3

Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species.

Wang J, Takahashi RH, DeMent K, Gustafson A, Kenny JR, Wong SG, Yan Z. Wang J, et al. Among authors: yan z. Anal Biochem. 2018 Sep 1;556:85-90. doi: 10.1016/j.ab.2018.06.025. Epub 2018 Jun 28. Anal Biochem. 2018. PMID: 29959909

4

Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis.

Chen YC, Kenny JR, Wright M, Hop CECA, Yan Z. Chen YC, et al. Among authors: yan z. J Pharm Sci. 2019 Mar;108(3):1296-1302. doi: 10.1016/j.xphs.2018.10.011. Epub 2018 Oct 14. J Pharm Sci. 2019. PMID: 30326208

5

Strategy for Determining the Free Fraction of Labile Covalent Modulators in Plasma Using Equilibrium Dialysis.

Leung C, Kenny JR, Hop CECA, Yan Z. Leung C, et al. Among authors: yan z. J Pharm Sci. 2020 Oct;109(10):3181-3189. doi: 10.1016/j.xphs.2020.06.029. Epub 2020 Jul 12. J Pharm Sci. 2020. PMID: 32663597

6

Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes.

Wang W, Teresa M, Cai J, Zhang C, Wong S, Yan Z, Khojasteh SC, Zhang D. Wang W, et al. Among authors: yan z. Xenobiotica. 2021 Jan;51(1):15-23. doi: 10.1080/00498254.2020.1795949. Epub 2020 Jul 27. Xenobiotica. 2021. PMID: 32713280

7

Application of empirical scalars to enable early prediction of human hepatic clearance using IVIVE in drug discovery: an evaluation of 173 drugs.

Jones RS, Leung C, Chang JH, Brown S, Liu N, Yan Z, Kenny JR, Broccatelli F. Jones RS, et al. Among authors: yan z. Drug Metab Dispos. 2022 May 30;50(8):DMD-AR-2021-000784. doi: 10.1124/dmd.121.000784. Drug Metab Dispos. 2022. PMID: 35636770

8

New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry.

Yan Z, Ma L, Huang J, Carione P, Kenny JR, Hop CECA, Wright M. Yan Z, et al. Anal Chem. 2023 Feb 28;95(8):4086-4094. doi: 10.1021/acs.analchem.2c04864. Epub 2023 Feb 15. Anal Chem. 2023. PMID: 36791153

9

Introducing the Dynamic Well-Stirred Model for Predicting Hepatic Clearance and Extraction Ratio.

Yan Z, Ma L, Carione P, Huang J, Hwang N, Kenny JR, Hop CECA. Yan Z, et al. J Pharm Sci. 2024 Apr;113(4):1094-1112. doi: 10.1016/j.xphs.2023.12.020. Epub 2024 Jan 12. J Pharm Sci. 2024. PMID: 38220087 Free article.

10

Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake.

Yan Z, Ma L, Hwang N, Huang J, Kenny JR, Hop CECA. Yan Z, et al. Drug Metab Dispos. 2024 May 16;52(6):548-554. doi: 10.1124/dmd.124.001645. Drug Metab Dispos. 2024. PMID: 38604729

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