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A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis.
Jung JH, Barbosa AD, Hutin S, Kumita JR, Gao M, Derwort D, Silva CS, Lai X, Pierre E, Geng F, Kim SB, Baek S, Zubieta C, Jaeger KE, Wigge PA. Jung JH, et al. Among authors: kumita jr. Nature. 2020 Sep;585(7824):256-260. doi: 10.1038/s41586-020-2644-7. Epub 2020 Aug 26. Nature. 2020. PMID: 32848244 Free article.
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM. Limbocker R, et al. Among authors: kumita jr. Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5. Nat Commun. 2019. PMID: 30644384 Free PMC article.
Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro.
Frankel D, Davies M, Bhushan B, Kulaberoglu Y, Urriola-Munoz P, Bertrand-Michel J, Pergande MR, Smith AA, Preet S, Park TJ, Vendruscolo M, Rankin KS, Cologna SM, Kumita JR, Cenac N, St John Smith E. Frankel D, et al. Among authors: kumita jr. Aging (Albany NY). 2020 Nov 4;12(21):22266-22290. doi: 10.18632/aging.202138. Epub 2020 Nov 4. Aging (Albany NY). 2020. PMID: 33147569 Free PMC article.
A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
Hagan CL, Johnson RJ, Dhulesia A, Dumoulin M, Dumont J, De Genst E, Christodoulou J, Robinson CV, Dobson CM, Kumita JR. Hagan CL, et al. Among authors: kumita jr. Protein Eng Des Sel. 2010 Jul;23(7):499-506. doi: 10.1093/protein/gzq023. Epub 2010 Apr 9. Protein Eng Des Sel. 2010. PMID: 20382744 Free PMC article.
89 results