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The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.
Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin TY, Liberatore KM, Bulaon DK, Kastenhuber ER, Mercadante MN, Shobana-Ganesh K, He L, Schwartz RE, Chen S, Weinstein H, Elemento O, Piskounova E, Nilsson-Payant BE, Lee G, Trimarco JD, Burke KN, Hamele CE, Chaparian RR, Harding AT, Tata A, Zhu X, Tata PR, Smith CM, Possemato AP, Tkachev SL, Hornbeck PV, Beausoleil SA, Anand SK, Aguet F, Getz G, Davidson AD, Heesom K, Kavanagh-Williamson M, Matthews D, tenOever BR, Cantley LC, Blenis J, Heaton NS. Yaron TM, et al. Among authors: heesom k. bioRxiv [Preprint]. 2020 Dec 16:2020.08.14.251207. doi: 10.1101/2020.08.14.251207. bioRxiv. 2020. PMID: 32817937 Free PMC article. Preprint.
Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
Lay AC, Tran VDT, Nair V, Betin V, Hurcombe JA, Barrington AF, Pope RJ, Burdet F, Mehl F, Kryvokhyzha D, Ahmad A, Sinton MC, Lewis P, Wilson MC, Menon R, Otto E, Heesom KJ, Ibberson M, Looker HC, Nelson RG, Ju W, Kretzler M, Satchell SC, Gomez MF, Coward RJM; BEAt-DKD consortium. Lay AC, et al. Among authors: heesom kj. Nat Commun. 2024 Nov 19;15(1):10018. doi: 10.1038/s41467-024-54089-1. Nat Commun. 2024. PMID: 39562547 Free PMC article.
Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics.
Dulyayangkul P, Beavis T, Lee WWY, Ardagh R, Edwards F, Hamilton F, Head I, Heesom KJ, Mounsey O, Murarik M, Pinweha P, Reding C, Satapoomin N, Shaw JM, Takebayashi Y, Tooke CL, Spencer J, Williams PB, Avison MB. Dulyayangkul P, et al. Among authors: heesom kj. PLoS Pathog. 2024 Jun 6;20(6):e1012235. doi: 10.1371/journal.ppat.1012235. eCollection 2024 Jun. PLoS Pathog. 2024. PMID: 38843111 Free PMC article.
Roles for CEP170 in cilia function and dynein-2 assembly.
Weijman JF, Vuolo L, Shak C, Pugnetti A, Mukhopadhyay AG, Hodgson LR, Heesom KJ, Roberts AJ, Stephens DJ. Weijman JF, et al. Among authors: heesom kj. J Cell Sci. 2024 Apr 15;137(8):jcs261816. doi: 10.1242/jcs.261816. Epub 2024 May 1. J Cell Sci. 2024. PMID: 38533689 Free PMC article.
160 results